Monday, September 19, 2022

Time
8:30am EDT12:00pm EDT

Artificial Intelligence-Based Approaches to Preclinical Pain Assessment

Tracks: Basic Science: Pain Models
Categories: Hands-On Workshop
Room: 803 A

Measurement of pain in non-human species in laboratory, clinical and domesticated environments is limited to surrogate outcome measures due to…

8:30am EDT12:00pm EDT

Assessment, Mechanism-Based Pharmacological and Interventional Treatment for Neuropathic Pain (NP)

Tracks: Neuropathic Pain
Categories: Refresher Course
Room: 601 A

• Dr. Nadine Attal will discuss the IASP Definition of NP, Diagnosis of NP using history (including NP questionnaires), physical…

8:30am EDT12:00pm EDT

C-Fibers – Small Their Diameter, Multifaceted in Their Function

Tracks: Clinical, Research Methods
Categories: Hands-On Workshop
Room: 801 B

C-Fibers play a large role in neuropathic pain conditions. Understanding of their function can aid tremendously in understanding different symptoms…

8:30am EDT12:00pm EDT

CRPS from Bedside to Bench

Tracks: Chronic Pain: Other
Categories: Refresher Course
Room: 602 B

CRPS is an uncommon condition. For such reasons, it may be challenging for clinicians to gain experience and knowledge of…

8:30am EDT12:00pm EDT

Cortical Signatures in Pain Conditions

Categories: Refresher Course
Room: 701 A

Discrete pain processing pathways are regulated differentially according to the cognitive status of the individual. In this refresher course the…

8:30am EDT12:00pm EDT

Intensive Interdisciplinary Pain Treatment for Pediatric Chronic Pain

Categories: Refresher Course
Room: 602 A

Chronic pain is a prevalent, highly disabling condition among children and adolescents, resulting in physical limitations, school absence, social problems,…

8:30am EDT12:00pm EDT

Modality-Specific Evoked Potentials – Methods to Objectify the Quality of Our Somatosensory System

Tracks: Assessment, Diagnosis And Measurement In Pain
Categories: Hands-On Workshop
Room: 803 B

We aim to present established and novel methods to generate evoked potentials recorded by EEGs. These procedures,some of them only…

8:30am EDT12:00pm EDT

Neuro-Immune Interactions in Chronic Pain – A Topical Overview

Categories: Refresher Course
Room: 601 B

Neuro-immune interactions are crucial to many chronic pain states. This workshop will not only provide an overview of the “classical…

8:30am EDT12:00pm EDT

Neuromodulation for Painful Diabetic Neuropathy: Mechanism of Action and Clinical Approach

Categories: Sig Symposia

In four succinct lectures, discover the most recent information on the role of neuromodulation in diabetic neuropathy. Presentations will be…

8:30am EDT12:00pm EDT

Pain & Work: Evidence Based Practice to Enhance Work Participation and Quality of Life

Tracks: Including Multi- And Inter-Disciplinary Approaches, Other - Clinical Intervention: Pain Management Programs, Physiotherapy And Rehabilitation
Categories: Refresher Course
Room: 701 B

This course will provide participants with state-of-the-art evidence on the interplay between chronic pain and work. The leading paradigm will…

8:30am EDT12:00pm EDT

The War Against Cancer Pain
Are We Winning?

Categories: Sig Symposia

New challenges arise in therapeutic options for cancer pain management. What do we do about the opioid crises in some…

8:30am EDT12:00pm EDT

Ultrasound for Pain Intervention Workshop: Peripheral Nerve

Tracks: Clinical Intervention: Interventional Approaches, Including Neuromodulation
Categories: Hands-On Workshop
Room: 801 A

The session will be a 3.5 hours program with 4 stations in each WS, 50 min each and 10 min…

8:30am EDT4:30pm EDT

Advances in Pediatric Pain Prevention and Treatment: From Basic Science to Clinical Application

Categories: Sig Symposia

The Symposium will bring together local, national, and international experts to share innovations, leading practices, and applied science in the…

8:30am EDT4:30pm EDT

Complexity of the Musculoskeletal System: Scientific Updates

Categories: Sig Symposia

There is a growing awareness of the adverse impact of musculoskeletal pain on wellbeing, healthy aging, disability, and economic stress.…

8:30am EDT4:30pm EDT

Discovering New Therapeutic Targets and Molecular Pain Mechanisms Using Human Tissues: Recent Advances, Emerging Pitfalls, Continuing Gaps in Knowledge

Categories: Sig Symposia

This symposium will take place over one day, consisting of interactive oral presentations from invited speakers, short oral presentations from…

8:30am EDT4:30pm EDT

Mechanisms of Orofacial Pain

Categories: Sig Symposia

This whole day symposium builds on the International Classification of Orofacial Pain (ICOP) published in early 2020. The first 2…

8:30am EDT4:30pm EDT

Multilevel Perspectives on the Social Foundations of Pain

Categories: Sig Symposia

The inaugural symposium of the IASP Social Aspects of Pain SIG (SocSIG) brings together some of the brightest minds in…

8:30am EDT4:30pm EDT

Pain, Mind, and Movement: Past, Present and Future

Categories: Sig Symposia

The SIG on Pain, Mind, and Movement is delighted to present a Symposium at the IASP World Congress on Pain…

8:30am EDT4:30pm EDT

Preventing Chronification of Acute Pain and its Consequences

Categories: Sig Symposia

The mission of the Acute Pain SIG is “to study underlying mechanisms of acute pain, including the transition from acute…

8:30am EDT4:30pm EDT

Technology, Innovation, and Progress Symposium in Pain Education

Categories: Sig Symposia

Pain Education is a global, interprofessional challenge. As pain science and knowledge has expanded dramatically in recent decades, pain education…

1:00pm EDT4:30pm EDT

An Evidence-Based Approach to Chronic Abdominopelvic Pain

Tracks: Abdominal And Pelvic Pain, Visceral
Categories: Refresher Course
Room: 602 B

Chronic abdominopelvic pain is a major public health problem worldwide, yet it is poorly understood and treated, with both pelvic…

1:00pm EDT4:30pm EDT

Building Resilience to Chronic Pain and Distress Through State of the Art Psychosocial Treatments

Tracks: Clinical Psychology
Categories: Hands-On Workshop
Room: 604

Chronic pain remains a challenge for patients and health care. The importance of psychosocial interventions to improve functioning and quality…

1:00pm EDT4:30pm EDT

Caring for Youth with Migraine and Other Headache Disorders: What the Evidence Suggests

Categories: Refresher Course
Room: 602 A

Practice Guidelines for the acute and preventive care of youth with migraine have recently been updated (Oskoui et al., Neurology…

1:00pm EDT4:30pm EDT

Concepts of Providing Standardized Sensory Testing Protocols in Developed and Developing Countries.

Tracks: Healthcare Systems And Pain Management, Including Developing World And Low Resource Settings
Categories: Hands-On Workshop
Room: 810

A brief introductory comprising 3x5min talks will be conducted first. The workshop includes 4 stations. The aim is to provide…

1:00pm EDT4:30pm EDT

Nerve Blocks for Management of Neuropathic Pain Disorders Affecting Head and Neck Region

Tracks: Headache And Orofacial Pain
Categories: Hands-On Workshop
Room: 603

Advances in imaging, cellular biology and genetics, and neuroscience in recent years have improved our understanding of chronic pain disorders.…

1:00pm EDT4:30pm EDT

Neuropathic Pain Assessment in Real Life: From the Bedside to the Lab

Tracks: Chronic Pain: Other
Categories: Refresher Course
Room: 601 A

This refresher course is intended to provide clinicians and basic scientists interested in practical aspects of neuropathic pain diagnosis with…

1:00pm EDT4:30pm EDT

Nociception and Neuroplasticity: Peripheral and Central Mechanisms

Categories: Refresher Course
Room: 601 B

The peripheral and central nervous systems work in concert to alert us to touch and/or painful stimulation. Peripheral inflammatory mediators…

1:00pm EDT4:30pm EDT

Placebo and Nocebo Effects: Basic Science and Implications for Clinical Trials and Clinical Practice

Tracks: Placebo
Categories: Refresher Course
Room: 701 B

During the last decade, psychological and neurobiological mechanisms underlying placebo and nocebo effects have been identified and by now it…

1:00pm EDT4:30pm EDT

Quality, Bias, and Integrity in Pain Research: Creating the Next Generation of Pain Science

Categories: Sig Symposia

Systematic review has highlighted how poor quality and biased primary studies can lead to misleading claims for efficacy and safety…

1:00pm EDT4:30pm EDT

Symposium on Analgesic Trials

Categories: Sig Symposia

The Clinical Trials SIG will present its half-day Symposia on Analgesic Trials as a Pre-Congress event on Monday, 19 September.  Join…

1:00pm EDT4:30pm EDT

The Central Amygdala in Chronic Pain – Circuit, Neuropeptides, and Nociplasticity

Tracks: Basic Science: Physiology
Categories: Refresher Course
Room: 701 A

Recently accumulated lines of evidence in these years indicate that a small limbic structure called the central amygdala (CeA) plays…

1:00pm EDT4:30pm EDT

The Wide Field of Emerging Therapies for Complex Regional Pain Syndrome

Categories: Sig Symposia

This symposium will feature short presentations about emerging therapies for CRPS and novel assessment methods, aiming to inform clinicians and…

1:00pm EDT4:30pm EDT

Ultrasound for Pain Intervention Workshop: Musculoskeletal Structures

Tracks: Clinical Intervention: Interventional Approaches, Including Neuromodulation
Categories: Hands-On Workshop
Room: 801 A

The session will be a 3.5 hours program with 4 stations in each WS, 50 min each and 10 min…

Tuesday, September 20, 2022

Time
8:15am EDT9:30am EDT

John J. Bonica Award Lecture: “Central Sensitization: Clinical Utility of a Physiological Concept for ICD-11 and Nociplastic Pain”

Categories: Plenary Lecture, Virtual Program
Room: Plenary Room (Exhibit Halls F/G)

The physiological concept of "central sensitization“ refers to a leftward shift of the stimulus-response functions of nociceptive neurons in the central nervous system, with lowered response thresholds, enhanced suprathreshold responses, new or enlarged receptive fields and increased spontaneous activity. According to the level of the central nervous system involved, one may distinguish spinal, brainstem and…

10:45am EDT12:15pm EDT
10:45am EDT12:15pm EDT

Functional Biomarkers of Nociceptive Signal Processing – Back-translation of Human Studies to Preclinical Models

Tracks: Novel Experimental/Analytic Approaches/Tools
Categories: Topical Workshop
Room: 718 B

There is a great need for functional biomarkers of nociceptive signal processing and pain translating from animals to humans. Drugs that are efficacious analgesics in preclinical models often prove to have negligible clinical efficacy. For more efficient analgesic development, robust translational measures are needed that can unequivocally prove that a drug has bound to and…

10:45am EDT12:15pm EDT

It’s Difficult to Make Predictions: Data Mining and Machine Learning in Pain Research and Management

Tracks: Coding And Pain Registries, Informatics
Categories: Topical Workshop
Room: 716 A

Prescribed and voluntary open data reporting practices, together with a growth in multinational research consortia, are generating medium to large clinical and experimental datasets of varying specificities and quality (in terms of pain information). These datasets provide avenues to explore complex relationships yet need innovative analysis approaches. In this workshop we will explore the application…

10:45am EDT12:15pm EDT

Making A Difference: Mobilizing Knowledge to Drive High Value Pain Care across the Lifespan: ‘What’ and ‘How’

Tracks: Other - Specific Pain Conditions/Pain In Specific Populations
Categories: Topical Workshop
Room: 716 B

This workshop will focus on a systems-wide approach to driving pain care reform for children and young people. We will discuss why driving reform is critical to supporting better access to, and delivery of, 'right' pain care for children and young people. ‘Right’ care weighs up benefits and harms, is patient-centred and informed, and is…

10:45am EDT12:15pm EDT

Moving Beyond The Means and Standard Deviations in Pain Research – Insights to Enhance Personalized Pain Care

Tracks: Novel Experimental/Analytic Approaches/Tools
Categories: Topical Workshop
Room: 715 A/B

Thinking about pain after surgery in terms of predictors for those with complex pain at a fixed postoperative time (e.g., 3 months, 1 year) limits our ability to understand the process of recovery and test interventions. While research and treatments during the COVID-19 pandemic initially focused on a dichotomous outcome (mortality), they rapidly evolved to…

10:45am EDT12:15pm EDT

Opioids in the Perioperative Setting: Should We Be Worried?

Tracks: Other -
Categories: Topical Workshop
Room: 701 B

The opioid epidemic is one of the only public health problems that continues to worsen throughout the world. While much of the focus has been placed on primary care and chronic pain prescribing, most people receive their first opioid exposure from an acute care episode, such as surgery. While opioids remain an important part of…

10:45am EDT12:15pm EDT

Pain in People with Intellectual and Developmental Disabilities Across the Life Span; Where Do We Go from Here?

Tracks: Pain In Special Populations
Categories: Topical Workshop
Room: 717 A/B

Children and adults living with intellectual and/or developmental disabilities (IDD) are at high risk of pain. The identification and assessment of pain are especially challenging among individuals with IDD whose communication abilities may be limited or absent. Treating pain is also challenging because there is limited evidence on pain management practices for individuals with IDD.…

10:45am EDT12:15pm EDT

Schwann Cell Renaissance In Pain: Critical Appraisal Of New Knowledge On Old Cells

Tracks: Mechanisms
Categories: Topical Workshop
Room: 713 A/B

The primary reason for inadequate analgesic effects of current pharmaceuticals for neuropathic pain is that we do not fully understand the pathophysiological mechanisms that underlie its development. We will discuss ground-breaking novel findings on potential peripheral mechanisms of neuropathic pain concentrating on the skin-nerve interface and presenting potential implications on clinical practice. Data from…

10:45am EDT12:15pm EDT

The Future of Psychological Assessment and Treatment is Wholly ‘Digital’

Tracks: Novel Experimental/Analytic Approaches/Tools
Categories: Topical Workshop, Virtual Program
Room: 718 A

Covid-19 has accelerated the adoption of telemedicine and Digital Therapeutics (DTx) for use in chronic pain. The conversation has changed from 'is it possible' to 'when will it be available'. In this debate we argue two strong opposing positions. First, Dr Keefe will argue that psychology is fundamentally a relational and interpretative activity, a scientific…

10:45am EDT12:15pm EDT

Translating Basic Models of Muscle Pain: A Focus on Sex Differences

Tracks: Gender/Sex Differences
Categories: Topical Workshop
Room: 714 A

One of the most common complaints of patients seeking medical treatment for pain is musculoskeletal in nature, yet this type of pain state is vastly understudied compared to numerous other pain conditions. Translation of preclinical studies of muscle pain to human conditions is therefore of outmost importance. However, one of the major issues in translational…

2:00pm EDT3:15pm EDT

Peripheral Neuroimmune Interactions Drive Itch and Inflammation

Categories: Plenary Lecture, Virtual Program
Room: Plenary Room (Exhibit Halls F/G)

Atopic dermatitis (AD) is the most common chronic itch disorder and affects ~10% of people worldwide. AD is an inflammatory disease associated with skin barrier disruption, inflammation, spontaneous activity of C-fibers, persistent itch, and, in a subset of patients, persistent pain. This talk will highlight the peripheral neuroimmune interactions that drive the development of itch…

2:00pm EDT3:15pm EDT

Sex, Gender and Pain: Past, Present and Future

Categories: Plenary Lecture, Virtual Program
Room: Plenary Room (Exhibit Halls F/G)

There are important differences between men and women in the perception and experience of pain. Women generally experience more pain across the lifespan when compared to men. However, there is variation in this pattern within as well as between men and women, which needs to be account for. The purpose of this review is to…

4:30pm EDT6:00pm EDT

A Translational Approach to Mechanistic-based Pain Medicine

Tracks: Assessment, Diagnosis & Measurement Of Pain
Categories: Topical Workshop, Virtual Program
Room: 718 A

The number-needed-to-treat (NNT) for most pharmaceutical therapies remains high. This could be explained by the non-selective manner with which chronic pain patients are prescribed analgesic regimens. Enrichment strategies for recruitment of patients in clinical trials might lower of NNT, but currently, this is rarely used in pain trials. Quantitative Sensory Testing (QST) is neurological examinations…

4:30pm EDT6:00pm EDT

Advancing the Science and Management of Chronic Pain through its Classification in ICD-11: Perspectives from Patient and Specialized Pain Clinic Viewpoints

Tracks: ICD-11 & ICF
Categories: Topical Workshop
Room: 715 A/B

For the first time, the newly implemented ICD-11 includes a comprehensive chronic pain classification that was developed by the IASP Task Force for the Classification of Chronic Pain in close cooperation with the World Health Organization (WHO). This classification provides clearly defined and operationalized diagnoses for chronic pain as either a symptom of some chronic…

4:30pm EDT6:00pm EDT

Chemotherapy-induced Peripheral Neuropathy: Pathophysiology and Mechanism-based Treatment

Tracks: Basic Science
Categories: Topical Workshop
Room: 717 A/B

CIPN is common following chemotherapy and is clinically poorly managed, thus understanding the underlying mechanisms could lead to more effective treatment. Nav1.6 but not Nav1.7 is important for the maintenance of vincristine-induced pain (VIP) in mice, while live imaging shows that paclitaxel increases trafficking of Nav1.7 to distal ends of sensory neuron axons, which is…

4:30pm EDT6:00pm EDT

Improving Reproducibility and Translatability in Pre-clinical Pain Research – some Practical Solutions

Tracks: Clinical Trials, Evidence, Guidelines And Implementation Science, Systematic Review
Categories: Topical Workshop
Room: 713 A/B

Are you tired of hearing about the reproducibility crisis and a failure of translation, without being offered tangible solutions? If so, this workshop is for you! We are offering positive and practical solutions to improve the impact of your pre-clinical experiments on the pain field. Franziska Denk will use novel insights from psychology to…

4:30pm EDT6:00pm EDT

Mechanisms Leading to the Female-Biased Nature of Migraine: Moving Beyond Estrogen

Tracks: Basic Science
Categories: Topical Workshop
Room: 714 A/B

Migraine is the second leading cause of disability worldwide. Women are disproportionately affected by migraine with prevalence at two- to three-times higher than in men. In women, migraine frequency is highest between puberty and menopause, attacks are often linked to the cycle, frequency of attacks can change across pregnancy, and they are often influenced by…

4:30pm EDT6:00pm EDT

No Singular Solution: Prescribing, Tapering, and the Opioid Pendulum Swing

Tracks: Clinical Trials, Evidence, Guidelines And Implementation Science, Systematic Review
Categories: Topical Workshop
Room: 701 B

This workshop explores real world implications for clinical practice and patient outcomes of national opioid prescribing guidelines in Europe and North America. Panelists, who will offer perspectives from different countries, will share their direct experience with research, clinical practice, and guideline development or oversight. Emerging studies suggest that some practices embraced either directly…

4:30pm EDT6:00pm EDT

Nocebo Effects in Pain: From Mechanisms to Therapeutic Treatments in Clinical Practice

Tracks: Placebo
Categories: Topical Workshop
Room: 716 A

Nocebo effects plays a critical role in pain management, influencing patients’ experience of pain and distress, post-operative pain, treatment satisfaction, adherence to treatment, therapeutic effectiveness, and the incidence of complications and adverse treatment effects. Placebo researchers have played an important role in the development of our understanding of how nocebo can influence pain and treatment…

4:30pm EDT6:00pm EDT

Patient Stratification in Chronic Pain by Quantitative Sensory Testing: Way Forward or Failure?

Tracks: Assessment, Diagnosis & Measurement Of Pain
Categories: Topical Workshop
Room: 718 B

“This house believes that sensory testing is useful for stratifying patients with chronic pain in treatment and clinical trials” There is no doubt that stratification of patients with chronic pain is crucial to improve the success of analgesic therapy and also to increase the number of successful clinical trials. However, it is unclear which instruments…

Wednesday, September 21, 2022

Time
8:15am EDT9:30am EDT

Cytokines and Pain

Categories: Plenary Lecture, Virtual Program
Presented By: Michaela Kress
Room: Plenary Room (Exhibit Halls F/G)

The treatment of chronic pain disorders remains challenging. Primary afferent nociceptors bidirectionally interact with immune cells and these interactions are causally involved in inflammation as well as the hyperfunction of the pain pathway resulting from a disbalance of pro- and anti-inflammatory processes. In particular, the pleiotropic pro-inflammatory mediators interleukin (IL) IL-1β, IL-6, TNF-α, GM-CSF and…

8:15am EDT9:30am EDT

John D. Loeser Award Lecture: The Biopsychosocial Model of Pain Is Now 40 Years Old: Time for a Reappraisal?

Categories: Plenary Lecture, Virtual Program
Room: Plenary Room (Exhibit Halls F/G)

The biopsychosocial model of pain has been generally credited with providing a unifying perspective for clinicians and researchers in extending our understanding of pain and guiding our treatments of pain (Dworkin et a., 2021). This model is commonly referred to in the opening lines of texts on pain and pain management. But it's not always…

10:45am EDT12:15pm EDT

Alpha Oscillations as a Potential Biomarker of Acute and Chronic Pain

Tracks: Imaging: Pain Imaging And Neuroimaging
Categories: Topical Workshop
Room: 715 A

The temporal code of neuronal activity underlying acute and chronic pain is not fully understood but is thought to involve neural oscillations at characteristic frequencies. In particular, alpha frequency oscillations have been recently linked to acute pain sensitivity and aspects of chronic pain and thus represent a potential pain biomarker. This workshop will provide an…

10:45am EDT12:15pm EDT

Angiotensin Receptor Signaling as a Pain Target: Bench, Bedside and Back-Translation

Tracks: Mechanisms
Categories: Topical Workshop
Room: 718 B

The major bioactive molecule in the renin-angiotensin system, the peptide hormone angiotensin II orchestrates many more processes than blood pressure alone. Angiotensin receptor agonists and antagonists have demonstrated efficacy in multiple disease models, particularly neuropathic pain states. This workshop will cover the background of angiotensin receptor signaling in the nervous and immune systems in the…

10:45am EDT12:15pm EDT

Nociplastic Pain – What Clinicians need to Understand: Recent Insights, Presentation of new Clinical Criteria and Future Development.

Tracks: Assessment, Diagnosis & Measurement Of Pain
Categories: Topical Workshop
Room: 714 A

The term nociplastic pain is a mechanistic descriptor adapted by IASP, alongside with nociceptive and neuropathic pain. Per definition, individuals suffering from nociplastic pain have altered nociception, i.e., pain hypersensitivity. However, as hypersensitivity is also seen in nociceptive and neuropathic pain conditions, and since patients often have combinations of several pain mechanisms, clinical criteria are…

10:45am EDT12:15pm EDT

Plexus Injury: Plasticity of the Human Dorsal Root Ganglion, Satellite Glia and Reinnervation

Tracks: Specific Pain Conditions/Pain In Specific Populations
Categories: Topical Workshop
Room: 715 B

Patients with traumatic plexus lesion suffer from palsy, sensory loss and pain related to the number of avulsed roots. Nerve grafting targets functional motor recovery, but often pain persists. Regeneration into the periphery and the CNS requires guiding structures and growth factors but also replacement of neuronal loss. To address this complex system, a thorough…

10:45am EDT12:15pm EDT

The Amygdala as a Master Generator of Pain Plasticity – from Nociceptive Amygdala to Nociplastic Amygdala

Tracks: Basic Science
Categories: Topical Workshop
Room: 717 A

For more than three decades, the amygdala has been at the forefront of neurophysiological studies to elucidate how pain affects brain networks. First, researchers found that neurons in the central amygdala (CeA) receive "nociceptive" inputs with a relay at the parabrachial nucleus (PBN) from the spinal and medullary dorsal horn and that CeA responses are…

10:45am EDT12:15pm EDT

What Are Sleeping C-Fiber Nociceptors? Taking a Question from Human Physiology to Experiment

Tracks: Other - Novel Experimental/Analytic Approaches/Tools
Categories: Topical Workshop
Room: 701 A

Studies in humans often reveal questions about patho-physiological phenomena which are not easily addressed by basic science. Lab research on the other hand often provides answers that are hard to translate into clinics. In this new workshop format, we will address the following questions arising from studies on human subjects: What are sleeping human nociceptors?…

10:45am EDT12:15pm EDT

What Role do Registers Play in Providing Safe and Effective Care for People with Chronic Pain?

Tracks: Treatment/Management
Categories: Topical Workshop
Room: 713 B

The use of “real world evidence”, complementing data from randomised controlled trials, is now commonly used to evaluate the effectiveness of approaches to management of patients with pain. Registries provide a potentially important source of such data. In contrast to RCTs which usually provide a comparison between two alternative treatments with short-term follow-up, data from…

10:45am EDT12:15pm EDT

What’s New in Combination Pharmacotherapy for Neuropathic Pain? From Bench to Bedside

Tracks: Treatment/Management
Categories: Topical Workshop, Virtual Program
Room: 718 A

Laura Stone will illustrate the therapeutic potential of combination pharmacotherapy by highlighting – with recent examples – additive and synergistic analgesic interactions using preclinical investigative techniques. The rationale for picking certain targets for combinations will be presented as will issues of adverse drug interactions. Ian Gilron will provide a recently updated evidence-based review…

2:00pm EDT3:15pm EDT

Mechanisms and Manifestations in Musculoskeletal Pain – from Experimental to Clinical Pain Settings

Categories: Plenary Lecture, Virtual Program
Room: Plenary Room (Exhibit Halls F/G)

Musculoskeletal pain is extremely frequent, a major socio-economic burden, and contemporary treatment is inadequate. Acute musculoskeletal pain presents with localised and referred pain as well as localised deep-tissue hyperalgesia, whereas chronic pain often presents with expanded pain areas and widespread hyperalgesia. The mechanistic interplay in the transition from acute to chronic musculoskeletal pain is unclear.…

2:00pm EDT3:15pm EDT

The Genesis of the Unequal Burden of Pain: A Selective Review Examining Social Inequities and Unheard Voices

Categories: Plenary Lecture, Virtual Program
Room: Plenary Room (Exhibit Halls F/G)

Title: The Genesis of the Unequal Burden of Pain: A Selective Review Examining Social Inequities and Unheard Voices Author: Carmen Renee Green, MD Dean, The City University of Medicine School of Medicine Bert Brodsky Chair Medical Professor, Community Health and Social Medicine Professor, Colin Powell School for Civic and Global Leadership Affilitation: The…

4:30pm EDT6:00pm EDT

Clinical Aspects of Tapering Opioids for Chronic Non-cancer Pain. Presentation of Research Results from UK, US and Canada

Tracks: Clinical Trials, Evidence, Guidelines And Implementation Science, Systematic Review
Categories: Topical Workshop
Room: 701 B

The panel will discuss three large research projects related to opioid tapering for chronic non-cancer pain in the UK, US and Canada. Dr. Harbinder Sandhu will show the results of the randomized controlled trial of opioid tapering in the UK (iWotch trial). Dr. Mark Sullivan will discuss the NIDA-funded STRIPE trial which is testing pain…

4:30pm EDT6:00pm EDT

Contribution of Itch, Inflammation, and the Microbiota to Colorectal Nociception; Opportunities for Therapeutic Intervention?

Tracks: Mechanisms
Categories: Topical Workshop
Room: 713 A

Visceral pain is a leading cause of morbidity for individuals suffering from gastrointestinal (GI) diseases. For many people the principal cause of pain is the development of visceral hypersensitivity, which triggers pain in response to previously innocuous stimuli within the bowel. Better understanding of the how and why we development visceral hypersensitivity is critical for…

4:30pm EDT6:00pm EDT

Generalization in the Context of Pain: Both Good and Bad?

Tracks: Mechanisms
Categories: Topical Workshop
Room: 717 A

Learning to predict danger is adaptive; it assists in anticipating and avoiding future harm. Given its intrinsically alarming function, pain is a potent motivator for learning –it stimulates the detection of stimuli predicting the occurrence of pain to avoid/minimize their impact. Adaptive learners however face the challenge of how to deal with variations in signaling…

4:30pm EDT6:00pm EDT

Mechanisms of Susceptibility/Resistance to Chronic Pain Development

Tracks: Mechanisms
Categories: Topical Workshop, Virtual Program
Room: 718 A

Basic and clinical chronic pain research has been focused on the individuals that manifest pain and on the mechanisms sustaining pain and related comorbidities. However, a relevant number of clinically characterized subjects, on similar conditions, do not manifest pain. Factors underlying such susceptibility/resistance to chronic pain development remain largely unknown though a relevant number of…

4:30pm EDT6:00pm EDT

Motor Control Adaptions in Low Back Pain: Do they Matter?

Tracks: Specific Pain Conditions/Pain In Specific Populations
Categories: Topical Workshop
Room: 717 B

Pain is accompanied by individual-specific motor control adaptions. In some individuals with low back pain (LBP), adapted motor control strategies may have consequences affecting cortical sensorimotor plasticity, spine kinematics and biomechanical outcomes such as motor variability, segmental loading and muscle activity, potentially affecting the persistence of LBP. Furthermore, psychological factors such as kinesiophobia and fear…

4:30pm EDT6:00pm EDT

News from the Brainstem: Functional Plasticity in Noradrenergic Nuclei upon Stress and Injury

Tracks: Basic Science
Categories: Topical Workshop
Room: 716 B

Multiple lines of evidence demonstrate that one important mechanism underpinning chronic pain is dysfunction of brainstem-origin noradrenergic-control pathways encompassed by the descending pain modulatory system (DPMS). This workshop will detail the latest knowledge regarding the functionality of key noradrenergic nuclei that govern nociceptive processing in health and disease, as we unpick the maladaptive plasticity that…

4:30pm EDT6:00pm EDT

Non-Neuronal Cells in Chronic Pain: From Single-Cell Analysis to Translational Targets

Tracks: Mechanisms
Categories: Topical Workshop
Room: 701 A

In this workshop, three speakers will discuss their recent research achievements in the field of glial biology and neuroimmunity in pain pathophysiology. Dr. Berta will present single-cell RNA sequencing data and the identification of the molecular heterogeneity of satellite glial cells (SGCs) and metalloproteinase signaling for the maintenance of homeostasis and discovery of new pain…

4:30pm EDT6:00pm EDT

Offset Analgesia: At the Crossroads of Pain Modulation and Chronicity

Tracks: Assessment, Diagnosis & Measurement Of Pain
Categories: Topical Workshop
Room: 718 B

Offset analgesia was first described in 2002 as a disproportionate decrease in perceived pain intensity following a slight incremental decrease in noxious stimulus intensity. Ever since, it has attracted much attention, both for the insights that it can provide into nociceptive processing mechanisms as well as for its clinical relevance to chronic pain. Together with…

4:30pm EDT6:00pm EDT

Pain Assessment in Dementia: Guidelines, Gaps, Automation and Knowledge Mobilization

Tracks: Pain In Special Populations
Categories: Topical Workshop
Room: 715 A

Pain in people with serious limitations in ability to communicate due to dementia is highly prevalent but frequently undertreated. Despite recent developments in validated observational approaches to pain assessment in dementia, there remain implementation challenges as well as gaps in research knowledge and in continuing education for health care providers. In this session we will…

4:30pm EDT6:00pm EDT

Transition to Chronic Pain: Risk Factors and Evidence for Prevention and Mitigation Strategies

Tracks: Specific Pain Conditions/Pain In Specific Populations
Categories: Topical Workshop
Room: 714 A

Simon Haroutounian will introduce and discuss postulated mechanisms for the transition to chronic pain after acute trauma and surgery. This will be followed by a comprehensive review of studies evaluating the evidence for various biopsychosocial risk factors for the development of chronic pain after surgery and/or acute traumatic injury. Based on this evidence, consideration will…

Thursday, September 22, 2022

Time
8:15am EDT9:30am EDT

Neuroimaging of Pain and Affect: Pathways, Biomarkers, and Interventions

Categories: Plenary Lecture, Virtual Program
Presented By: Prof. Tor D. Wager
Room: Plenary Room (Exhibit Halls F/G)

Pain and related forms of affect are central to human life. Their experience defines our wellbeing, and the brain processes that underlie them drive behavior and learning. Developing models of the brain circuits that underlie them, and how they interact, could transform how we understand and measure them, and provide biological targets for interventions ranging…

8:15am EDT9:30am EDT

Ronald Melzack Award Lecture: Mosaic of “Pain Genes” and Biological Pathways Contributing to Human Pain

Categories: Plenary Lecture, Virtual Program
Room: Plenary Room (Exhibit Halls F/G)

The molecular pathophysiology of chronic pain is largely unknown. The genetic and molecular studies of human pain can nevertheless provide critical insights into pathophysiological mechanisms of pain states. Genome-wide “omics” approaches allow a whole human genome scan that is hypothesis-free and permit systematic use and integration of multiple genome-wide datasets, resulting in the unbiased interpretation…

10:45am EDT12:15pm EDT

2022 Genes, Environments and Development in Pain: Crossing the Translational Divide

Tracks: Basic Science
Categories: Topical Workshop
Room: 715 A

How do genetic and environmental factors influence pain in early life and in turn influence pain experience in adulthood? Exposure to adverse experiences during early life are known to predispose to a wide variety of health issues of varying severity in later life, including chronic pain. The underlying neurobiological mechanisms that underlie these effects remain…

10:45am EDT12:15pm EDT

Health Professionals’ Pain Management Education – Strategy to Action Through Partnership and Engagement

Tracks: Education
Categories: Topical Workshop
Room: 713 A

Health professionals pain management education and training is underpinned by the aim of improving the care and lives of people living with pain. To attain this goal, education initiatives need to sit within a broader strategic framework; readily translate into practice in an appropriate and sustainable way; achieve set outcomes; and have positive impact within…

10:45am EDT12:15pm EDT

Mechanistic Brain-based Treatments for Chronic Pain

Tracks: Treatment/Management
Categories: Topical Workshop
Room: 701 A

There is ample evidence that brain mechanisms contribute to the development and maintenance of chronic pain. Such mechanisms involve sensitization with changes in primary somatosensory cortex and insula, a shift from nociceptive to emotional brain networks, alterations in somatosensory and motor processing, dysfunctional reward processing involving prefrontal and striatal networks or deficient processing of and…

10:45am EDT12:15pm EDT

Pain Sensitivity and Chronic Pain During Critical Periods in Life- Studies in Neonatal, Adolescents and Elderly

Tracks: Pain In Special Populations
Categories: Topical Workshop
Room: 717 B

Critical periods are stages in the lifespan of extensive changes in the human body characterized by a unique set of developmental and maturational changes. These changes affect the pain system in unique ways, leading to alterations in pain sensitivity and ultimately, the development of chronic pain. Identifying changes unique to each period will allow a…

10:45am EDT12:15pm EDT

Phenotyping Pain Mechanisms in Low Back Pain: Modulatory Factors and Clinical Utility

Tracks: Specific Pain Conditions/Pain In Specific Populations
Categories: Topical Workshop, Virtual Program
Room: 718 A

Treatment success for back pain patients without curable pathophysiological or pathoanatomical cause, is limited by imprecise mechanistic assessment in clinical practice. Research in recent years has substantially refined and validated mechanistic pain assessment of individual patients. In this workshop, state of the art assessment of pro-nociceptive mechanisms such as widespread hyperalgesia and facilitated temporal summation…

10:45am EDT12:15pm EDT

Skin Biopsy: From a Diagnostic Tool to a Powerful Asset for Basic and Translational Research in Peripheral Neuropathic Pain

Tracks: Other - Other
Categories: Topical Workshop
Room: 718 B

This workshop explores novel technologies applied to skin biopsy taken from patients with painful peripheral neuropathy as powerful tools to advance our understanding of the mechanisms by which non-neuronal cells in the skin communicate with cutaneous afferents and how this communication impacts peripheral neuropathic pain. First Dr. Lauria will provide an update on the evolution…

10:45am EDT12:15pm EDT

Translational Evidence for Pain-Cognition Interactions: Insights from Laboratory Animal, Human Experimental and Clinical Studies

Tracks: Mechanisms
Categories: Topical Workshop
Room: 713 B

Pain perception is not linearly related to nociceptive input, but is subject to many modulatory factors including cognitive processes (e.g. catastrophizing, perceived self-efficacy and distraction). Pain is not only shaped by cognitive processes, pain also interferes with cognition. Patients with chronic pain report cognitive deficits, further reducing their quality of life. Acute pain also interferes…

2:00pm EDT3:15pm EDT

Lessons for Clinicians and Researchers Across the Lifespan: What Acute Pain Research with Young Children Can Teach Us All

Categories: Plenary Lecture, Virtual Program
Room: Plenary Room (Exhibit Halls F/G)

Despite centuries of research focused on elucidating answers regarding pain, research continues to progress without a definitive essential definition. Using research from the largest longitudinal studies to date studying the development of acute pain responses over the first five years of life, the current paper reviews four key lessons about understanding pain that reverberates across…

2:00pm EDT3:15pm EDT

Neuronal Interactions with Microbes in Pain and Host Defense

Categories: Plenary Lecture, Virtual Program
Presented By: Isaac Chiu
Room: Plenary Room (Exhibit Halls F/G)

The sensory nervous system is constantly exposed to microbes at barrier tissues such as the skin and gut. We and other have found that nociceptors can directly sense bacteria and their products to mediate pain. During gram-positive infections, nociceptors can directly detect bacterial pore-forming toxins and signal to immune cells to modulate the outcome of…

4:30pm EDT6:00pm EDT

Basic and Clinical Research Exploring Acupuncture Therapy for Pain

Tracks: Placebo
Categories: Topical Workshop
Room: 717 B

Acupuncture in an ancient medical technique originated in China. By inserting thin needles into body at specific anatomical locations, improvements in a range of symptoms, especially painful conditions, have been reported empirically and by many meta-analyses of clinical trials. However, the therapeutic values of acupuncture for pain management are fraught with controversy, largely due to…

4:30pm EDT6:00pm EDT

From Gut Feelings to Memories of Visceral Pain: Mechanisms and Clinical Perspectives for Disorders of Gut-Brain Interactions

Tracks: Specific Pain Conditions/Pain In Specific Populations
Categories: Topical Workshop
Room: 713 B

Visceral pain is an important yet often underestimated clinical and societal problem. From a clinical perspective, visceral pain is highly prevalent, causes enormous suffering and significant healthcare expenditures. Effective treatment is notoriously difficult, owing at least in part to its complex etiology involving the gut-brain axis. Visceral pain is highly modifiable by psychological factors, and…

4:30pm EDT6:00pm EDT

Large-scale Studies Elucidating Pain and Sensitivity in a Life-course

Tracks: Assessment, Diagnosis & Measurement Of Pain
Categories: Topical Workshop
Room: 714 A

The pain system undergoes structural and functional adaptation during the life course. Important stages during the life span may either prime or cause future pain conditions. Mapping pain symptoms, pain sensitivity, and pain mechanisms across life course and sex can provide important information on how the pain system is changed in pain conditions. Dr. Graven-Nielsen…

4:30pm EDT6:00pm EDT

Molecular Pathophysiology of Pain Resolution

Tracks: Genetics
Categories: Topical Workshop, Virtual Program
Room: 718 A

The molecular pathophysiology of chronic pain states is largely unknown. The genetic and molecular studies of pain in both humans and mice nevertheless can provide critical insights into pathophysiological mechanisms of pain chronification. Increasing evidence suggests that resolution of actue pain requires an active molecular process and production of specilized pro-resolving mediators (SPMs). Failure in…

4:30pm EDT6:00pm EDT

Neurobiological Mechanisms and Clinical Relevance of Stress-pain Interactions

Tracks: Mechanisms
Categories: Topical Workshop
Room: 715 A

The relationship between stress and pain is complex and multi-layered. Stress has been known to produce hyperalgesic and hypoalgesic effects depending on various factors. Individual reactions to pain (e.g., catastrophizing) can trigger a psycho-neuro-endocrine response that negatively impacts pain. Multiple brain pathways (e.g., thalamocorticoamygdala) and systems (e.g., endogenous opioid and cannabinoid systems) are central to…

4:30pm EDT6:00pm EDT

Pain in Osteoarthritis

Tracks: Specific Pain Conditions/Pain In Specific Populations
Categories: Topical Workshop
Room: 718 B

Osteoarthritis is prevalent, and the prevalence is expected to increase in future due to increasing level of obesity and increasing age in the general population. Osteoarthritis is characterized by cartilage degeneration, joint stiffness, and pain. X-ray imaging remains the golden standard to assess cartilage generation, but no to limited association is found comparing x-ray findings…

4:30pm EDT6:00pm EDT

The Burden of Not Knowing: The Role of Uncertainty Chronic Pain Disability

Tracks: Mechanisms
Categories: Topical Workshop
Room: 713 A

Learning to predict danger is adaptive; it assists in anticipating and avoiding harm. Given its intrinsically alarming function, pain is a potent motivator for learning –it stimulates the detection of stimuli predicting the occurrence of pain to minimize their impact. Protective responses (fear/avoidance) are adaptive and promote recovery, yet when pain no longer signals bodily…

4:30pm EDT6:00pm EDT

Utilization of Pain Biomarkers as the Basis for Decisions in the Therapeutic Development Process and in Clinical Practice: New Approaches from INTEGRATE-Pain

Tracks: Assessment, Diagnosis & Measurement Of Pain
Categories: Topical Workshop
Room: 715 B

The workshop will open with an introduction to the INTEGRATE-Pain consortium, which seeks to improve the understanding and treatment of pain through transatlantic R&D. It will also provide an overview of different categories of biomarkers and how each type can be integrated into the therapy development process and clinical practice. The session will then feature…

4:30pm EDT6:00pm EDT

Which Structural and Functional Changes in Skin Nociceptors Cause Chronic Pain?

Tracks: Mechanisms
Categories: Topical Workshop
Room: 716 B

The key question of this topical workshop is which neuropathic changes in epidermal nociceptors can lead to chronic pain and how can we specifically assess the underlying changes in excitability. Beyond mere nerve fiber reduction as a frequent hallmark of small fiber neuropathy (SFN), we propose to look into which cues facilitate or inhibit epidermal…

Friday, September 23, 2022

Time
8:15am EDT9:30am EDT

Nonopioid Analgesics Discovery and the Valley of Death – EMA401 from Concept to Clinical Trial

Categories: Plenary Lecture, Virtual Program
Presented By: Prof. Maree T Smith
Room: Plenary Room (Exhibit Halls F/G)

Success in translating promising preclinical efficacy data for molecules from analgesics discovery programs to positive clinical trial outcomes is limited, despite the large collective effort to date1. Root cause analysis reveals many upstream obstacles impeding success. These include incomplete knowledge on chronic pain mechanisms, inappropriate analgesic drug target selection, insufficient drug target engagement at clinically…

8:15am EDT9:30am EDT

William D. Willis, Jr., M.D., Ph.D. Memorial Lecture Award: Using Molecular Profiling to Understand Heterogeneity of Nociceptors

Categories: Plenary Lecture, Virtual Program
Presented By: Prof. Patrik Ernfors
Room: Plenary Room (Exhibit Halls F/G)

Distinct types of sensory neurons have unique contributions to somatosensation and pain. A comprehensive classification of sensory neurons is crucial to understanding how the different types contribute to our ability to experience heat, cold, touch, and pain. Molecular and cellular insights also open for an understanding of the origins and mechanisms that cause chronic pain.…

10:45am EDT12:15pm EDT

From Cells to Humans’ Pain (and Back) – Translational Pain Research is More than Just a Vision

Tracks: Other - Mechanisms
Categories: Topical Workshop
Room: 714 B

This workshop will provide a lively discussion about possible ways to approach translation pain research by three protagonists within this field. Each of the three presenters will give a brief overview about their way of performing translational pain research. Cheryl Stucky will talk about her recent translational approaches by using rodent models of chronic pain…

10:45am EDT12:15pm EDT

Non-invasive Neuromodulation of Brain Rhythms – How Can We Translate Basic Insights into Novel Pain Treatments?

Tracks: Treatment/Management
Categories: Topical Workshop
Room: 715 B

Neuronal oscillations, or brain rhythms, are a basic feature of neuronal signaling and communication. They can be recorded at different locations and frequencies from very low frequencies below 1 Hz up to 100 Hz. Recent studies in animals and humans have provided converging evidence that brain rhythms play a crucial role in the processing of…

10:45am EDT12:15pm EDT

Novel Biomarkers in Painful Neuropathies – Recent Advances in Magnetic Resonance Imaging (MRI), Microneurography, and non-coding RNAs

Tracks: Assessment, Diagnosis & Measurement Of Pain
Categories: Topical Workshop
Room: 701 B

This workshop focuses on novel biomarkers for peripheral neuropathy and neuropathic pain. In the first session Matthew Evans will discuss the development of MR neurography, and its application to some common neuropathies such as diabetic neuropathy. He will explore the current state of the art, share experience with high field (7 Tesla) imaging of peripheral…

10:45am EDT12:15pm EDT

Pain, Substance Use Disorders and Suicide: Epidemiology, Theory, Assessment and Mitigation

Tracks: Specific Pain Conditions/Pain In Specific Populations
Categories: Topical Workshop
Room: 713 A

Individuals with chronic pain commonly have significant concomitant psychiatric and medical disorders placing them at higher risk for death by suicide. A seminal systematic review revealed that the risk of successful suicide was doubled in patients with chronic pain as compared to non-pain controls. Individuals with substance use disorders are also highly susceptible to suicidal…

10:45am EDT12:15pm EDT

Taking, Processing, Analyzing, Learning: Skin Punch Biopsies – More Than Just Fiber Count

Tracks: Novel Experimental/Analytic Approaches/Tools
Categories: Topical Workshop
Room: 714 A

One histological hallmark of neuropathies is loss of intraepidermal nerve fibers, as shown by skin punch biopsy from the distal and proximal leg. While the procedure is fast and simple, even small but strategic inaccuracies may lead to clinically relevant misinterpretations. Following standardized guidelines for processing and analyzing skin samples is mandatory to ensure accurate…

10:45am EDT12:15pm EDT

The Intersection of Pain and the Opioid Epidemic Across the Lifespan: Scalable Behavioral Solutions

Tracks: Clinical Trials, Evidence, Guidelines And Implementation Science, Systematic Review
Categories: Topical Workshop
Room: 716 B

Chronic pain and opioid use disorders have become significant and integrally related health concerns across the lifespan, affecting millions of individuals worldwide. Undertreated pain is a modifiable contributor to opioid misuse and use disorders. Developmental changes during adolescence make youth susceptible to chronic pain with continuation into adulthood, with pain being a primary driver of…

10:45am EDT12:15pm EDT

The Intersection of Sleep and Pain: Mechanistic Implications for Opioid, Placebo, and Positive Affective Analgesia

Tracks: Mechanisms
Categories: Topical Workshop
Room: 716 A

Despite a clear understanding that sleep and pain consistently covary in patients with clinical pain, we have not yet translated that knowledge to produce reliable interventions that harness sleep protocols to enhance analgesia. This may be due to our limited understanding of mechanisms accounting for the association of sleep and analgesia. This workshop focuses on…

10:45am EDT12:15pm EDT

The Intersection of Trauma and Pain: Translation across Children, Adults, and Animals

Tracks: Pain In Special Populations
Categories: Topical Workshop, Virtual Program
Room: 718 A

Painful experiences (e.g. surgeries, injuries) can be traumatic for individuals of any age, but adverse experiences and trauma in early life of humans and other mammals appear to have an important role in the development of enduring pain problems. Surprisingly little research has examined the trauma-pain relationship in early life or the underlying mechanisms that…

10:45am EDT12:15pm EDT

Understanding the Complexity of Painful Chronic Inflammatory Diseases

Tracks: Specific Pain Conditions/Pain In Specific Populations
Categories: Topical Workshop
Room: 715 A

Chronic inflammatory conditions are common. Approximately 10% women have endometriosis, ~0.5% of the adult population have a diagnosis of inflammatory bowel disease (IBD) and ~1% a confirmed diagnosis of rheumatoid arthritis. All these conditions have pain as a key symptom, yet current therapies tend to target the inflammatory pathology and the extent to which pain…

4:30pm EDT6:00pm EDT

Conditioned Pain Modulation (CPM): To Be or Not To Be?

Tracks: Assessment, Diagnosis & Measurement Of Pain
Categories: Topical Workshop
Room: 717 A

This house believes that conditioned pain modulation (CPM) is a useful tool for research and clinical work. This is based on many studies showing less efficient CPM in pain patients, especially in the nociplastic disorders, and on studies that show prediction by CPM of future pain after interventions such as surgery as well as response…

4:30pm EDT6:00pm EDT

Demystifying Mechanisms of Placebo Effects Across the Lifespan

Tracks: Placebo
Categories: Topical Workshop
Room: 714 A

The placebo effect is one of the most striking and well-known demonstrations of the mind’s influence on the experience of pain. While for decades clinical trials have aimed to reduce the placebo effect, there is growing interest in leveraging the placebo effect to improve pain treatments and to relieve suffering. This includes moving beyond a…

4:30pm EDT6:00pm EDT

Increasing the Capacity for Delivering Interdisciplinary Pain Management in Southeast Asia: A Model for Lower Resource Regions

Tracks: Education
Categories: Topical Workshop
Room: 718 B

Despite strong evidence of the impact of pain burden globally, there is a mismatch between burden and resources for improving access to effective pain management services. This mismatch is especially evident in low resource countries. While there is often access to unimodal therapies, such as nerve blocks and drugs, they are of limited value in…

4:30pm EDT6:00pm EDT

Introducing Optical Imaging Advances to Unravel Chronic Pain Mechanisms

Tracks: Imaging: Pain Imaging And Neuroimaging
Categories: Topical Workshop, Virtual Program
Room: 718 A

Despite important advances in identifying molecular mechanisms in nociceptive sensitization, we are still far from treating pain disorders adequately. A major hindrance has been that the nature of neural circuits that mediate pain is not well understood and decoding how pain is generated and maintained remains a challenge. Although seminal insights have emerged from human…

4:30pm EDT6:00pm EDT

Mutual Facilitation of Pain and Emotional Dysregulation – Recent Advances of Understanding in Rodents and Human Patients with Major Depression

Tracks: Mechanisms
Categories: Topical Workshop
Room: 715 B

Pain is often accompanied by co-morbid anxiety and depression. This workshop will elucidate mechanisms of pain and emotional dysregulation interaction in rodents and humans. Min Zhuo will detail two forms of long-term potentiation (LTP) in the anterior cingulate cortex (ACC); a presynaptic form (pre-LTP) requiring kainate receptors and a postsynaptic form (post-LTP) requiring N-methyl-D-aspartate…

4:30pm EDT6:00pm EDT

Nocebo Effects in the Covid-19 Area: How does Information about Side-effects Influence Actual Side-effects and How can we Mitigate these Effects? Finding Across Three Continents

Tracks: Placebo
Categories: Topical Workshop
Room: 715 A

It is well-know that information about side-effects may lead to side-effects. Yet, less is known about the general public’s knowledge of this phenomenon and how that may decrease or increase the negative effects. The pandemic has allowed for a detailed and world-wide comparisons of how expectations of side effects influence actual side effects following COVID-19…

4:30pm EDT6:00pm EDT

Novel Peripheral Mechanisms of Neuro-immune Crosstalk in Chronic Pain

Tracks: Mechanisms
Categories: Topical Workshop
Room: 716 A

This workshop will elucidate novel mechanisms whereby non-neuronal cells in peripheral tissues drive neuroinflammation and chronic pain. New data will be presented that reveal important roles for keratinocytes, adipocytes (fat cells), muscle macrophages, and B cells in the onset and maintenance of different types of chronic pain. In the first presentation, Dr. Matthieu Talagas will…

4:30pm EDT6:00pm EDT

Promoting the Engagement of Patient Partners in the Planning, Conduct and Knowledge Translation of Clinical Pain Research: Findings and Consensus Recommendations from the 2021 International Multi-Stakeholder IMMPACT Meeting

Tracks: Patient Engagement And Co-creation In Research And Education
Categories: Topical Workshop
Room: 714 B

This workshop is informed by the proceedings of the October 2021 IMMPACT (Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials) Meeting: “Patient Engagement in the Planning, Conduct, and Dissemination of Clinical Pain Research.” This meeting was organized by the public-private partnership – ACTTION (Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and…

4:30pm EDT6:00pm EDT

Stress, Pain and Reward, Evolving Neuroscience with Therapeutic Implications

Tracks: Basic Science
Categories: Topical Workshop
Room: 713 A

The role of stress in the propensity to chronic pain is increasingly recognized. Allostasis, described as achieving stability through change, is an adaptation that accommodates potential threats through a process of learning (conditioning). A state of chronic deviation of the regulatory system from its normal (homeostatic) operating level is defined as an allostatic state. Stressors…

5:00pm EDT6:30pm EDT

Elucidating Pain Mechanism with Venom-Derived Peptides and Natural Toxins: What Doesn’t Kill You Might Treat Your Pain

Categories: Plenary Lecture, Virtual Program
Presented By: Dr. Irina Vetter
Room: Plenary Room (Exhibit Halls F/G)

Pain following envenomation is a well-known phenomenon: touching a nettle, stepping on a bee or becoming wrapped in jellyfish tentacles are relatively common encounters in our lives, and all of these have in common the memorable, and at times severe, pain that results. Indeed, pain-causing venoms and toxins have evolved on numerous occasions in many…

Filter by Category







Filter by Track













































All time and dates subject to change.

Commercial exhibits are open Tuesday through Friday 09:00-18:00.

Please note: Coffee breaks overlap with Poster Discussion periods. All coffee breaks are served in the Exhibition/Poster Hall.  Coffee breaks will be available on Friday afternoon from 16:00-16:15.

* Continuing education credits will not be offered by IASP for Symposia, Breakfast Symposia/Expert Sessions, Member-Supported Symposia,  SIG Satellite Symposia, or Company Presentations in the Innovation Labs.