Monday, September 19, 2022
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| 8:30am EDT–12:00pm EDT | Artificial Intelligence-Based Approaches to Preclinical Pain AssessmentTracks: Basic Science: Pain Models Categories: Hands-On Workshop Presented By: Dr. Nick Andrews, Dr. Guorong Wu, Dr. Rick B. D’Eath, Dr. Duncan Lascelles, Ms. Liezl Maree, Professor Gregory G Neely, Dr. David P. Roberson, Daniel Pang, Robert Bonin Room: 803 A Measurement of pain in non-human species in laboratory, clinical and domesticated environments is limited to surrogate outcome measures due to… |
| 8:30am EDT–12:00pm EDT | Assessment, Mechanism-Based Pharmacological and Interventional Treatment for Neuropathic Pain (NP)Tracks: Neuropathic Pain Categories: Refresher Course Room: 601 A • Dr. Nadine Attal will discuss the IASP Definition of NP, Diagnosis of NP using history (including NP questionnaires), physical… |
| 8:30am EDT–12:00pm EDT | C-Fibers – Small Their Diameter, Multifaceted in Their FunctionTracks: Research Methods, Clinical Categories: Hands-On Workshop Presented By: Prof. Lars Arendt-Nielsen, Dr. Leigh Nattkemper, Professor Martin Schmelz, Manon Sendel Room: 801 B C-Fibers play a large role in neuropathic pain conditions. Understanding of their function can aid tremendously in understanding different symptoms… |
| 8:30am EDT–12:00pm EDT | CRPS from Bedside to BenchTracks: Chronic Pain: Other Categories: Refresher Course Presented By: Professor Frank Birklein, Dr. Andreas Goebel, Professor Frank Huygen, Dr. Jennifer S. Lewis Room: 602 B CRPS is an uncommon condition. For such reasons, it may be challenging for clinicians to gain experience and knowledge of… |
| 8:30am EDT–12:00pm EDT | Cortical Signatures in Pain ConditionsCategories: Refresher Course Presented By: Dr. Karen D. Davis, Prof. Thomas Graven-Nielsen, Prof. Markus Ploner, Prof. David A. Seminowicz Room: 701 A Discrete pain processing pathways are regulated differentially according to the cognitive status of the individual. In this refresher course the… |
| 8:30am EDT–12:00pm EDT | Modality-Specific Evoked Potentials – Methods to Objectify the Quality of Our Somatosensory SystemTracks: Assessment, Diagnosis & Measurement Of Pain, Assessment, Diagnosis And Measurement In Pain Categories: Hands-On Workshop Presented By: Professor Andrea Truini, Ms. Sophie-Charlotte Fabig, Professor Luis Garcia-Larrea, Dr. Josephine Lassen, Dr. Jan Rosner Room: 803 B We aim to present established and novel methods to generate evoked potentials recorded by EEGs. These procedures,some of them only… |
| 8:30am EDT–12:00pm EDT | Neuro-Immune Interactions in Chronic Pain – A Topical OverviewCategories: Refresher Course Room: 601 B Neuro-immune interactions are crucial to many chronic pain states. This workshop will not only provide an overview of the “classical… |
| 8:30am EDT–12:00pm EDT | Pain & Work: Evidence Based Practice to Enhance Work Participation and Quality of LifeTracks: Other - Clinical Intervention: Pain Management Programs, Physiotherapy And Rehabilitation, Including Multi- And Inter-Disciplinary Approaches Categories: Refresher Course Room: 701 B This course will provide participants with state-of-the-art evidence on the interplay between chronic pain and work. The leading paradigm will… |
| 8:30am EDT–12:00pm EDT | The War Against Cancer Pain |
| 8:30am EDT–12:00pm EDT | Ultrasound for Pain Intervention Workshop: Peripheral NerveTracks: Clinical Intervention: Interventional Approaches, Including Neuromodulation Categories: Hands-On Workshop Presented By: Dr. Geoff Bellingham, Professor Sushma Bhatnagar, Professor Michele Curatolo, Dr. Mauricio Forero, Dr. James S. Khan, Professor Philip W. Peng Room: 801 A The session will be a 3.5 hours program with 4 stations in each WS, 50 min each and 10 min… |
| 8:30am EDT–4:30pm EDT | Advances in Pediatric Pain Prevention and Treatment: From Basic Science to Clinical ApplicationCategories: Sig Symposia The Symposium will bring together local, national, and international experts to share innovations, leading practices, and applied science in the… |
| 8:30am EDT–4:30pm EDT | Discovering New Therapeutic Targets and Molecular Pain Mechanisms Using Human Tissues: Recent Advances, Emerging Pitfalls, Continuing Gaps in KnowledgeCategories: Sig Symposia This symposium will take place over one day, consisting of interactive oral presentations from invited speakers, short oral presentations from… |
| 8:30am EDT–4:30pm EDT | Multilevel Perspectives on the Social Foundations of PainCategories: Sig Symposia The inaugural symposium of the IASP Social Aspects of Pain SIG (SocSIG) brings together some of the brightest minds in… |
| 8:30am EDT–4:30pm EDT | Pain, Mind, and Movement: Past, Present and FutureCategories: Sig Symposia The SIG on Pain, Mind, and Movement is delighted to present a Symposium at the IASP World Congress on Pain… |
| 8:30am EDT–4:30pm EDT | Preventing Chronification of Acute Pain and its ConsequencesCategories: Sig Symposia The mission of the Acute Pain SIG is “to study underlying mechanisms of acute pain, including the transition from acute… |
| 8:30am EDT–4:30pm EDT | Technology, Innovation, and Progress Symposium in Pain EducationCategories: Sig Symposia Pain Education is a global, interprofessional challenge. As pain science and knowledge has expanded dramatically in recent decades, pain education… |
| 9:00am EDT–4:30pm EDT | Complexity of the Musculoskeletal System: Scientific UpdatesCategories: Sig Symposia There is a growing awareness of the adverse impact of musculoskeletal pain on wellbeing, healthy aging, disability, and economic stress.… |
| 9:30am EDT–4:30pm EDT | Mechanisms of Orofacial PainCategories: Sig Symposia This whole day symposium builds on the International Classification of Orofacial Pain (ICOP) published in early 2020. The first 2… |
| 11:45am EDT–4:30pm EDT | Symposium on Analgesic TrialsCategories: Sig Symposia The Clinical Trials SIG will present its half-day Symposia on Analgesic Trials as a Pre-Congress event on Monday, 19 September. Join… |
| 1:00pm EDT–4:30pm EDT | An Evidence-Based Approach to Chronic Abdominopelvic PainTracks: Visceral, Abdominal And Pelvic Pain Categories: Refresher Course Presented By: Prof. Katy F. Vincent, Prof. Stuart Brierley, Dr. Sandra Hilton, Prof. Jeffrey Lackner Room: 602 B Chronic abdominopelvic pain is a major public health problem worldwide, yet it is poorly understood and treated, with both pelvic… |
| 1:00pm EDT–4:30pm EDT | Building Resilience to Chronic Pain and Distress Through State of the Art Psychosocial TreatmentsTracks: Clinical Psychology Categories: Hands-On Workshop Presented By: Dr. Rikard K. Wicksell, Prof. Julia Glombiewski, Prof. Mark P Jensen, Dr. Laura Simons Room: 604 Chronic pain remains a challenge for patients and health care. The importance of psychosocial interventions to improve functioning and quality… |
| 1:00pm EDT–4:30pm EDT | Concepts of Providing Standardized Sensory Testing Protocols in Developed and Developing Countries.Tracks: Healthcare Systems And Pain Management, Including Developing World And Low Resource Settings Categories: Hands-On Workshop Presented By: Jan Vollert, Miroslav Backonja, Martine Bordeleau, Dr. Julia Forstenpointner, Dr. Simon Haroutounian, Dr. Harriet Kemp, Mr. Walter Magerl, Professor Supranee Niruthisard, Ellen L Schaldemose Room: 810 A brief introductory comprising 3x5min talks will be conducted first. The workshop includes 4 stations. The aim is to provide… |
| 1:00pm EDT–4:30pm EDT | Nerve Blocks for Management of Neuropathic Pain Disorders Affecting Head and Neck RegionTracks: Headache And Orofacial Pain Categories: Hands-On Workshop Presented By: Dr. Shruti Handa, Professor Annika Rosen, Jeffrey R. Shaefer, Dr. Khawaja Shehryar Nasir Room: 603 Advances in imaging, cellular biology and genetics, and neuroscience in recent years have improved our understanding of chronic pain disorders.… |
| 1:00pm EDT–4:30pm EDT | Neuropathic Pain Assessment in Real Life: From the Bedside to the LabTracks: Chronic Pain: Other Categories: Refresher Course Room: 601 A This refresher course is intended to provide clinicians and basic scientists interested in practical aspects of neuropathic pain diagnosis with… |
| 1:00pm EDT–4:30pm EDT | Nociception and Neuroplasticity: Peripheral and Central MechanismsCategories: Refresher Course Room: 601 B The peripheral and central nervous systems work in concert to alert us to touch and/or painful stimulation. Peripheral inflammatory mediators… |
| 1:00pm EDT–4:30pm EDT | Placebo and Nocebo Effects: Basic Science and Implications for Clinical Trials and Clinical PracticeTracks: Placebo Categories: Refresher Course Room: 701 B During the last decade, psychological and neurobiological mechanisms underlying placebo and nocebo effects have been identified and by now it… |
| 1:00pm EDT–4:30pm EDT | The Central Amygdala in Chronic Pain – Circuit, Neuropeptides, and NociplasticityTracks: Basic Science: Physiology Categories: Refresher Course Room: 701 A Recently accumulated lines of evidence in these years indicate that a small limbic structure called the central amygdala (CeA) plays… |
| 1:00pm EDT–4:30pm EDT | The Wide Field of Emerging Therapies for Complex Regional Pain SyndromeCategories: Sig Symposia This symposium will feature short presentations about emerging therapies for CRPS and novel assessment methods, aiming to inform clinicians and… |
| 1:00pm EDT–4:30pm EDT | Ultrasound for Pain Intervention Workshop: Musculoskeletal StructuresTracks: Clinical Intervention: Interventional Approaches, Including Neuromodulation Categories: Hands-On Workshop Presented By: Dr. Anuj Bhatia, Professor Michele Curatolo, Dr. Roderick Finlayson, Dr. Nimish Mittal, Professor Philip W. Peng, Dr. Dmitri Souza Room: 801 A The session will be a 3.5 hours program with 4 stations in each WS, 50 min each and 10 min… |
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Tuesday, September 20, 2022
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| 8:15am EDT–9:30am EDT | John J. Bonica Award Lecture: “Central Sensitization: Clinical Utility of a Physiological Concept for ICD-11 and Nociplastic Pain”Categories: Plenary Lecture, Virtual Program Presented By: Prof. Rolf-Detlef Treede Room: Plenary Room Level 800 The physiological concept of „central sensitization“ refers to a leftward shift of the stimulus-response functions of nociceptive neurons in the central nervous system, with lowered response thresholds, enhanced suprathreshold responses, new or enlarged receptive fields and increased spontaneous activity. We currently know three distinct types of central sensitization: spinal, brainstem and thalamo-cortical. Use-dependent synaptic plasticity… |
| 10:45am EDT–12:15pm EDT | Calcitonin Gene-Related Peptide and PainCategories: Topical Workshop Room: 701 A Calcitonin gene-related peptide (CGRP) is widely distributed in nociceptive pathways in human peripheral and central nervous system and its receptors are also expressed in pain pathways. CGRP is involved in pathophysiology of primary headaches but its role in non-headache pain has not been clarified. The Joint IHS-IASP Symposium will focus on CGRP involvement in cephalic… |
| 10:45am EDT–12:15pm EDT | Functional Biomarkers of Nociceptive Signal Processing Back-Translation of Human Studies to Preclinical ModelsTracks: Novel Experimental/Analytic Approaches/Tools Categories: Topical Workshop Room: 718 B There is a great need for functional biomarkers of nociceptive signal processing and pain translating from animals to humans. Drugs that are efficacious analgesics in preclinical models often prove to have negligible clinical efficacy. For more efficient analgesic development, robust translational measures are needed that can unequivocally prove that a drug has bound to and… |
| 10:45am EDT–12:15pm EDT | It’s Difficult to Make Predictions: Data Mining and Machine Learning in Pain Research and ManagementTracks: Informatics, Coding And Pain Registries Categories: Topical Workshop Room: 716 A Prescribed and voluntary open data reporting practices, together with a growth in multinational research consortia, are generating medium to large clinical and experimental datasets of varying specificities and quality (in terms of pain information). These datasets provide avenues to explore complex relationships yet need innovative analysis approaches. In this workshop we will explore the application… |
| 10:45am EDT–12:15pm EDT | Making A Difference: Mobilizing Knowledge to Drive High Value Pain Care across the Lifespan: ‘What’ and ‘How’Tracks: Other - Specific Pain Conditions/Pain In Specific Populations Categories: Topical Workshop Room: 716 B This workshop will focus on a systems-wide approach to driving pain care reform for children and young people. We will discuss why driving reform is critical to supporting better access to, and delivery of, 'right' pain care for children and young people. ‘Right’ care weighs up benefits and harms, is patient-centred and informed, and is… |
| 10:45am EDT–12:15pm EDT | Moving Beyond The Means and Standard Deviations in Pain Research – Insights to Enhance Personalized Pain CareTracks: Novel Experimental/Analytic Approaches/Tools Categories: Topical Workshop Room: 715 A/B Thinking about pain after surgery in terms of predictors for those with complex pain at a fixed postoperative time (e.g., 3 months, 1 year) limits our ability to understand the process of recovery and test interventions. While research and treatments during the COVID-19 pandemic initially focused on a dichotomous outcome (mortality), they rapidly evolved to… |
| 10:45am EDT–12:15pm EDT | Opioids in the Perioperative Setting: Should We Be Worried?Tracks: Other - Categories: Topical Workshop Room: 701 B The opioid epidemic is one of the only public health problems that continues to worsen throughout the world. While much of the focus has been placed on primary care and chronic pain prescribing, most people receive their first opioid exposure from an acute care episode, such as surgery. While opioids remain an important part of… |
| 10:45am EDT–12:15pm EDT | Pain in People with Intellectual and Developmental Disabilities Across the Life Span: Where Do We Go from Here?Tracks: Pain In Special Populations Categories: Topical Workshop Presented By: Dr. Abraham J. Valkenburg, Professor Ruth Defrin, Professor Brian McGuire, Professor Frank Symons Room: 717 A/B Children and adults living with intellectual and/or developmental disabilities (IDD) are at high risk of pain. The identification and assessment of pain are especially challenging among individuals with IDD whose communication abilities may be limited or absent. Treating pain is also challenging because there is limited evidence on pain management practices for individuals with IDD.… |
| 10:45am EDT–12:15pm EDT | Schwann Cell Renaissance In Pain: Critical Appraisal Of New Knowledge On Old CellsTracks: Mechanisms Categories: Topical Workshop Room: 713 A/B The primary reason for inadequate analgesic effects of current pharmaceuticals for neuropathic pain is that we do not fully understand the pathophysiological mechanisms that underlie its development. We will discuss ground-breaking novel findings on potential peripheral mechanisms of neuropathic pain concentrating on the skin-nerve interface and presenting potential implications on clinical practice. Data from… |
| 10:45am EDT–12:15pm EDT | The Future of Psychological Assessment and Treatment is Wholly ‘Digital’Tracks: Novel Experimental/Analytic Approaches/Tools Categories: Topical Workshop, Virtual Program Room: 718 A Covid-19 has accelerated the adoption of telemedicine and Digital Therapeutics (DTx) for use in chronic pain. The conversation has changed from 'is it possible' to 'when will it be available'. In this debate we argue two strong opposing positions. First, Dr Keefe will argue that psychology is fundamentally a relational and interpretative activity, a scientific… |
| 10:45am EDT–12:15pm EDT | Translating Basic Models of Muscle Pain: A Focus on Sex DifferencesTracks: Gender/Sex Differences Categories: Topical Workshop Room: 711 One of the most common complaints of patients seeking medical treatment for pain is musculoskeletal in nature, yet this type of pain state is vastly understudied compared to numerous other pain conditions. Translation of preclinical studies of muscle pain to human conditions is therefore of outmost importance. However, one of the major issues in translational… |
| 2:00pm EDT–3:15pm EDT | Peripheral Neuroimmune Interactions Drive Itch and InflammationCategories: Plenary Lecture, Virtual Program Presented By: Prof. Diana M. Bautista Room: Plenary Room Level 800 Atopic dermatitis (AD) is the most common chronic itch disorder and affects ~10% of people worldwide. AD is an inflammatory disease associated with skin barrier disruption, inflammation, spontaneous activity of C-fibers, persistent itch, and, in a subset of patients, persistent pain. This talk will highlight the peripheral neuroimmune interactions that drive the development of itch… |
| 2:00pm EDT–3:15pm EDT | Sex, Gender and Pain: Past, Present and FutureCategories: Plenary Lecture, Virtual Program Presented By: Professor Edmund Keogh Room: Plenary Room Level 800 There are differences between men and women in the perception and experience of pain. Women generally experience more pain across the lifespan when compared to men. However, there is variation in this pattern within as well as between men and women, which needs to be accounted for. The purpose of this talk is to provide… |
| 4:30pm EDT–6:00pm EDT | A Translational Approach to Mechanistic-Based Pain MedicineTracks: Assessment, Diagnosis & Measurement Of Pain Categories: Topical Workshop, Virtual Program Room: 718 A The number-needed-to-treat (NNT) for most pharmaceutical therapies remains high. This could be explained by the non-selective manner with which chronic pain patients are prescribed analgesic regimens. Enrichment strategies for recruitment of patients in clinical trials might lower of NNT, but currently, this is rarely used in pain trials. Quantitative Sensory Testing (QST) is neurological examinations… |
| 4:30pm EDT–6:00pm EDT | Advancing the Science and Management of Chronic Pain through its Classification in ICD-11: Perspectives from Patient and Specialized Pain Clinic ViewpointsTracks: ICD-11 & ICF Categories: Topical Workshop Presented By: Dr. Young-Chang Arai, Dr. Maria Kleinstaeuber, Prof. Winfried Rief, Prof. Rolf-Detlef Treede Room: 715 A/B For the first time, the newly implemented ICD-11 includes a comprehensive chronic pain classification that was developed by the IASP Task Force for the Classification of Chronic Pain in close cooperation with the World Health Organization (WHO). This classification provides clearly defined and operationalized diagnoses for chronic pain as either a symptom of some chronic… |
| 4:30pm EDT–6:00pm EDT | Chemotherapy-Induced Peripheral Neuropathy: Pathophysiology and Mechanism-Based TreatmentTracks: Basic Science Categories: Topical Workshop Room: 717 A/B CIPN is common following chemotherapy and is clinically poorly managed, thus understanding the underlying mechanisms could lead to more effective treatment. Nav1.6 but not Nav1.7 is important for the maintenance of vincristine-induced pain (VIP) in mice, while live imaging shows that paclitaxel increases trafficking of Nav1.7 to distal ends of sensory neuron axons, which is… |
| 4:30pm EDT–6:00pm EDT | Improving Reproducibility and Translatability in Pre-Clinical Pain Research Some – Practical SolutionsTracks: Evidence - Clinical Trials - Systematic Review - Guidelines - Implementation Science, Evidence, Clinical Trials, Systematic Review, Guidelines And Implementation Science Categories: Topical Workshop Room: 713 A/B Are you tired of hearing about the reproducibility crisis and a failure of translation, without being offered tangible solutions? If so, this workshop is for you! We are offering positive and practical solutions to improve the impact of your pre-clinical experiments on the pain field. Franziska Denk will use novel insights from psychology to… |
| 4:30pm EDT–6:00pm EDT | Mechanisms Leading to the Female-Biased Nature of Migraine: Moving Beyond EstrogenTracks: Basic Science Categories: Topical Workshop Presented By: Professor Gregory Dussor, Professor Antoinette Maassen MaassenVanDenBrink, Professor Frank Porreca Room: 711 Migraine is the second leading cause of disability worldwide. Women are disproportionately affected by migraine with prevalence at two- to three-times higher than in men. In women, migraine frequency is highest between puberty and menopause, attacks are often linked to the cycle, frequency of attacks can change across pregnancy, and they are often influenced by… |
| 4:30pm EDT–6:00pm EDT | No Singular Solution: Prescribing, Tapering, and the Opioid Pendulum SwingTracks: Evidence - Clinical Trials - Systematic Review - Guidelines - Implementation Science, Evidence, Clinical Trials, Systematic Review, Guidelines And Implementation Science Categories: Topical Workshop Room: 701 B This workshop explores real world implications for clinical practice and patient outcomes of national opioid prescribing guidelines in Europe and North America. Panelists, who will offer perspectives from different countries, will share their direct experience with research, clinical practice, and guideline development or oversight. Emerging studies suggest that some practices embraced either directly… |
| 4:30pm EDT–6:00pm EDT | Nocebo Effects in Pain: From Mechanisms to Therapeutic Treatments in Clinical PracticeTracks: Placebo Categories: Topical Workshop Room: 716 A Nocebo effects plays a critical role in pain management, influencing patients’ experience of pain and distress, post-operative pain, treatment satisfaction, adherence to treatment, therapeutic effectiveness, and the incidence of complications and adverse treatment effects. Placebo researchers have played an important role in the development of our understanding of how nocebo can influence pain and treatment… |
| 4:30pm EDT–6:00pm EDT | Patient Stratification in Chronic Pain by Quantitative Sensory Testing: Way Forward or Failure?Tracks: Assessment, Diagnosis & Measurement Of Pain Categories: Topical Workshop Room: 718 B “This house believes that sensory testing is useful for stratifying patients with chronic pain in treatment and clinical trials” There is no doubt that stratification of patients with chronic pain is crucial to improve the success of analgesic therapy and also to increase the number of successful clinical trials. However, it is unclear which instruments… |
Wednesday, September 21, 2022
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| 8:15am EDT–9:30am EDT | Cytokines and PainCategories: Plenary Lecture, Virtual Program Presented By: Professor Michaela Kress Room: Plenary Room Level 800 The session addresses bidirectionally crosstalk of immune cells with neurons along the pain pathway and how and these interactions are causally involved in inflammation as well as the hyperfunction of the pain pathway resulting from a disbalance of pro- and anti-inflammatory processes. In particular, the pleiotropic pro-inflammatory mediators interleukin (IL) IL-1β, IL-6, TNF-α, GM-CSF and… |
| 8:15am EDT–9:30am EDT | John D. Loeser Award Lecture: The Biopsychosocial Model of Pain Is Now 40 Years Old: Time for a Reappraisal?Categories: Plenary Lecture, Virtual Program Presented By: Professor Michael K Nicholas Room: Plenary Room Level 800 The biopsychosocial model of pain has been generally credited with providing a unifying perspective for clinicians and researchers in extending our understanding of pain and guiding our treatments of pain (Dworkin et a., 2021). This model is commonly referred to in the opening lines of texts on pain and pain management. But it’s not always… |
| 10:45am EDT–12:15pm EDT | Alpha Oscillations as a Potential Biomarker of Acute and Chronic PainTracks: Imaging: Pain Imaging And Neuroimaging Categories: Topical Workshop Room: 715 A The temporal code of neuronal activity underlying acute and chronic pain is not fully understood but is thought to involve neural oscillations at characteristic frequencies. In particular, alpha frequency oscillations have been recently linked to acute pain sensitivity and aspects of chronic pain and thus represent a potential pain biomarker. This workshop will provide an… |
| 10:45am EDT–12:15pm EDT | Angiotensin Receptor Signaling as a Pain Target: Bench, Bedside and Back-TranslationTracks: Mechanisms Categories: Topical Workshop Room: 718 B The major bioactive molecule in the renin-angiotensin system, the peptide hormone angiotensin II orchestrates many more processes than blood pressure alone. Angiotensin receptor agonists and antagonists have demonstrated efficacy in multiple disease models, particularly neuropathic pain states. This workshop will cover the background of angiotensin receptor signaling in the nervous and immune systems in the… |
| 10:45am EDT–12:15pm EDT | Nociplastic Pain – What Clinicians Need to Understand: Recent Insights, Presentation of New Clinical Criteria and Future DevelopmentTracks: Assessment, Diagnosis & Measurement Of Pain Categories: Topical Workshop Room: 714 A The term nociplastic pain is a mechanistic descriptor adapted by IASP, alongside with nociceptive and neuropathic pain. Per definition, individuals suffering from nociplastic pain have altered nociception, i.e., pain hypersensitivity. However, as hypersensitivity is also seen in nociceptive and neuropathic pain conditions, and since patients often have combinations of several pain mechanisms, clinical criteria are… |
| 10:45am EDT–12:15pm EDT | Plexus Injury: Plasticity of the Human Dorsal Root Ganglion, Satellite Glia and ReinnervationTracks: Specific Pain Conditions/Pain In Specific Populations Categories: Topical Workshop Room: 715 B Patients with traumatic plexus lesion suffer from palsy, sensory loss and pain related to the number of avulsed roots. Nerve grafting targets functional motor recovery, but often pain persists. Regeneration into the periphery and the CNS requires guiding structures and growth factors but also replacement of neuronal loss. To address this complex system, a thorough… |
| 10:45am EDT–12:15pm EDT | The Amygdala as a Master Generator of Pain Plasticity – From Nociceptive Amygdala to Nociplastic AmygdalaTracks: Basic Science Categories: Topical Workshop Room: 717 A For more than three decades, the amygdala has been at the forefront of neurophysiological studies to elucidate how pain affects brain networks. First, researchers found that neurons in the central amygdala (CeA) receive "nociceptive" inputs with a relay at the parabrachial nucleus (PBN) from the spinal and medullary dorsal horn and that CeA responses are… |
| 10:45am EDT–12:15pm EDT | What Are Sleeping C-Fiber Nociceptors? Taking a Question from Human Physiology to ExperimentTracks: Other - Novel Experimental/Analytic Approaches/Tools Categories: Topical Workshop Room: 716 A Studies in humans often reveal questions about patho-physiological phenomena which are not easily addressed by basic science. Lab research on the other hand often provides answers that are hard to translate into clinics. In this new workshop format, we will address the following questions arising from studies on human subjects: What are sleeping human nociceptors?… |
| 10:45am EDT–12:15pm EDT | What Role do Registries play in Providing Safe and Effective Care for People in Chronic Pain?Tracks: Treatment/Management Categories: Topical Workshop Room: 713 B The use of “real world evidence”, complementing data from randomised controlled trials, is now commonly used to evaluate the effectiveness of approaches to management of patients with pain. Registries provide a potentially important source of such data. In contrast to RCTs which usually provide a comparison between two alternative treatments with short-term follow-up, data from… |
| 10:45am EDT–12:15pm EDT | What’s New in Combination Pharmacotherapy for Neuropathic Pain? From Bench to BedsideTracks: Treatment/Management Categories: Topical Workshop, Virtual Program Room: 718 A Laura Stone will illustrate the therapeutic potential of combination pharmacotherapy by highlighting – with recent examples – additive and synergistic analgesic interactions using preclinical investigative techniques. The rationale for picking certain targets for combinations will be presented as will issues of adverse drug interactions. Ian Gilron will provide a recently updated evidence-based review… |
| 2:00pm EDT–3:15pm EDT | Mechanisms and Manifestations in Musculoskeletal Pain – From Experimental to Clinical Pain SettingsCategories: Plenary Lecture, Virtual Program Presented By: Prof. Thomas Graven-Nielsen Room: Plenary Room Level 800 Musculoskeletal pain is extremely frequent, a major socio-economic burden, and contemporary treatment is inadequate. Acute musculoskeletal pain presents with localised and referred pain as well as localised deep-tissue hyperalgesia, whereas chronic pain often presents with expanded pain areas and widespread hyperalgesia. The mechanistic interplay in the transition from acute to chronic musculoskeletal pain is unclear.… |
| 2:00pm EDT–3:15pm EDT | The Genesis of the Unequal Burden of Pain: A Selective Review Examining Social Inequities and Unheard VoicesCategories: Plenary Lecture, Virtual Program Presented By: Dr. Carmen Renee Green Room: Plenary Room Level 800 Title: The Genesis of the Unequal Burden of Pain: A Selective Review Examining Social Inequities and Unheard Voices Author: Carmen Renee Green, MD Dean, The City University of New York School of Medicine Bert Brodsky Chair Medical Professor, Community Health and Social Medicine Professor, Colin Powell School for Civic and Global Leadership Affiliation:… |
| 4:30pm EDT–6:00pm EDT | Clinical Aspects of Tapering Opioids for Chronic Non-Cancer Pain. Presentation of Research Results from UK, US and CanadaTracks: Evidence - Clinical Trials - Systematic Review - Guidelines - Implementation Science, Evidence, Clinical Trials, Systematic Review, Guidelines And Implementation Science Categories: Topical Workshop Room: 713 B The panel will discuss three large research projects related to opioid tapering for chronic non-cancer pain in the UK, US and Canada. Dr. Harbinder Sandhu will show the results of the randomized controlled trial of opioid tapering in the UK (iWotch trial). Dr. Mark Sullivan will discuss the NIDA-funded STRIPE trial which is testing pain… |
| 4:30pm EDT–6:00pm EDT | Contribution of Itch, Inflammation, and the Microbiota to Colorectal Nociception: Opportunities for Therapeutic Intervention?Tracks: Mechanisms Categories: Topical Workshop Room: 713 A Visceral pain is a leading cause of morbidity for individuals suffering from gastrointestinal (GI) diseases. For many people the principal cause of pain is the development of visceral hypersensitivity, which triggers pain in response to previously innocuous stimuli within the bowel. Better understanding of the how and why we development visceral hypersensitivity is critical for… |
| 4:30pm EDT–6:00pm EDT | Generalization in the Context of Pain: Both Good and Bad?Tracks: Mechanisms Categories: Topical Workshop Room: 717 A Learning to predict danger is adaptive; it assists in anticipating and avoiding future harm. Given its intrinsically alarming function, pain is a potent motivator for learning –it stimulates the detection of stimuli predicting the occurrence of pain to avoid/minimize their impact. Adaptive learners however face the challenge of how to deal with variations in signaling… |
| 4:30pm EDT–6:00pm EDT | Mechanisms of Susceptibility/Resistance to Chronic Pain DevelopmentTracks: Mechanisms Categories: Topical Workshop, Virtual Program Room: 718 A Basic and clinical chronic pain research has been focused on the individuals that manifest pain and on the mechanisms sustaining pain and related comorbidities. However, a relevant number of clinically characterized subjects, on similar conditions, do not manifest pain. Factors underlying such susceptibility/resistance to chronic pain development remain largely unknown though a relevant number of… |
| 4:30pm EDT–6:00pm EDT | Motor Control Adaptions in Low Back Pain: Do They Matter?Tracks: Specific Pain Conditions/Pain In Specific Populations Categories: Topical Workshop Room: 717 B Pain is accompanied by individual-specific motor control adaptions. In some individuals with low back pain (LBP), adapted motor control strategies may have consequences affecting cortical sensorimotor plasticity, spine kinematics and biomechanical outcomes such as motor variability, segmental loading and muscle activity, potentially affecting the persistence of LBP. Furthermore, psychological factors such as kinesiophobia and fear… |
| 4:30pm EDT–6:00pm EDT | News from the Brainstem: Functional Plasticity in Noradrenergic Nuclei Upon Stress and InjuryTracks: Basic Science Categories: Topical Workshop Room: 716 B Multiple lines of evidence demonstrate that one important mechanism underpinning chronic pain is dysfunction of brainstem-origin noradrenergic-control pathways encompassed by the descending pain modulatory system (DPMS). This workshop will detail the latest knowledge regarding the functionality of key noradrenergic nuclei that govern nociceptive processing in health and disease, as we unpick the maladaptive plasticity that… |
| 4:30pm EDT–6:00pm EDT | Non-Neuronal Cells in Chronic Pain: From Single-Cell Analysis to Translational TargetsTracks: Mechanisms Categories: Topical Workshop Room: 716 A In this workshop, three speakers will discuss their recent research achievements in the field of glial biology and neuroimmunity in pain pathophysiology. Dr. Berta will present single-cell RNA sequencing data and the identification of the molecular heterogeneity of satellite glial cells (SGCs) and metalloproteinase signaling for the maintenance of homeostasis and discovery of new pain… |
| 4:30pm EDT–6:00pm EDT | Offset Analgesia: At the Crossroads of Pain Modulation and ChronicityTracks: Assessment, Diagnosis & Measurement Of Pain Categories: Topical Workshop Room: 718 B Offset analgesia was first described in 2002 as a disproportionate decrease in perceived pain intensity following a slight incremental decrease in noxious stimulus intensity. Ever since, it has attracted much attention, both for the insights that it can provide into nociceptive processing mechanisms as well as for its clinical relevance to chronic pain. Together with… |
| 4:30pm EDT–6:00pm EDT | Pain Assessment in Dementia: Guidelines, Gaps, Automation and Knowledge MobilizationTracks: Pain In Special Populations Categories: Topical Workshop Room: 715 A Pain in people with serious limitations in ability to communicate due to dementia is highly prevalent but frequently undertreated. Despite recent developments in validated observational approaches to pain assessment in dementia, there remain implementation challenges as well as gaps in research knowledge and in continuing education for health care providers. In this session we will… |
| 4:30pm EDT–6:00pm EDT | Transition to Chronic Pain: Risk Factors and Evidence for Prevention and Mitigation StrategiesTracks: Specific Pain Conditions/Pain In Specific Populations Categories: Topical Workshop Room: 714 A Simon Haroutounian will introduce and discuss postulated mechanisms for the transition to chronic pain after acute trauma and surgery. This will be followed by a comprehensive review of studies evaluating the evidence for various biopsychosocial risk factors for the development of chronic pain after surgery and/or acute traumatic injury. Based on this evidence, consideration will… |
Thursday, September 22, 2022
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| 8:15am EDT–9:30am EDT | Neuroimaging of Pain and Affect: Pathways, Biomarkers, and InterventionsCategories: Plenary Lecture, Virtual Program Presented By: Prof. Tor D. Wager Room: Plenary Room Level 800 Pain and related forms of affect are central to human life. Their experience defines our wellbeing, and the brain processes that underlie them drive behavior and learning. Developing models of the brain circuits that underlie them, and how they interact, could transform how we understand and measure them, and provide biological targets for interventions ranging… |
| 8:15am EDT–9:30am EDT | Ronald Melzack Award Lecture: Mosaic of “Pain Genes” and Biological Pathways Contributing to Human PainCategories: Plenary Lecture, Virtual Program Presented By: Dr. Luda Diatchenko Room: Plenary Room Level 800 The molecular pathophysiology of chronic pain is largely unknown. The genetic and molecular studies of human pain can nevertheless provide critical insights into pathophysiological mechanisms of pain states. Genome-wide “omics” approaches allow a whole human genome scan that is hypothesis-free and permit systematic use and integration of multiple genome-wide datasets, resulting in the unbiased interpretation… |
| 10:45am EDT–12:15pm EDT | 2022 Genes, Environments and Development in Pain: Crossing the Translational DivideTracks: Basic Science Categories: Topical Workshop Room: 715 A How do genetic and environmental factors influence pain in early life and in turn influence pain experience in adulthood? Exposure to adverse experiences during early life are known to predispose to a wide variety of health issues of varying severity in later life, including chronic pain. The underlying neurobiological mechanisms that underlie these effects remain… |
| 10:45am EDT–12:15pm EDT | Health Professionals’ Pain Management Education – Strategy to Action Through Partnership and EngagementTracks: Education Categories: Topical Workshop Room: 713 A Health professionals pain management education and training is underpinned by the aim of improving the care and lives of people living with pain. To attain this goal, education initiatives need to sit within a broader strategic framework; readily translate into practice in an appropriate and sustainable way; achieve set outcomes; and have positive impact within… |
| 10:45am EDT–12:15pm EDT | Mechanistic Brain-Based Treatments for Chronic PainTracks: Treatment/Management Categories: Topical Workshop Room: 701 A There is ample evidence that brain mechanisms contribute to the development and maintenance of chronic pain. Such mechanisms involve sensitization with changes in primary somatosensory cortex and insula, a shift from nociceptive to emotional brain networks, alterations in somatosensory and motor processing, dysfunctional reward processing involving prefrontal and striatal networks or deficient processing of and… |
| 10:45am EDT–12:15pm EDT | Pain Sensitivity and Chronic Pain During Critical Periods in Life: Studies in Neonatal, Adolescents and ElderlyTracks: Pain In Special Populations Categories: Topical Workshop Room: 717 B Critical periods are stages in the lifespan of extensive changes in the human body characterized by a unique set of developmental and maturational changes. These changes affect the pain system in unique ways, leading to alterations in pain sensitivity and ultimately, the development of chronic pain. Identifying changes unique to each period will allow a… |
| 10:45am EDT–12:15pm EDT | Phenotyping Pain Mechanisms in Low Back Pain: Modulatory Factors and Clinical UtilityTracks: Specific Pain Conditions/Pain In Specific Populations Categories: Topical Workshop, Virtual Program Presented By: Prof. David Walsh, Prof. Thomas Graven-Nielsen, Professor Paul W. Hodges, Dr. Megan McPhee Room: 718 A Treatment success for back pain patients without curable pathophysiological or pathoanatomical cause, is limited by imprecise mechanistic assessment in clinical practice. Research in recent years has substantially refined and validated mechanistic pain assessment of individual patients. In this workshop, state of the art assessment of pro-nociceptive mechanisms such as widespread hyperalgesia and facilitated temporal summation… |
| 10:45am EDT–12:15pm EDT | Skin Biopsy: From a Diagnostic Tool to a Powerful Asset for Basic and Translational Research in Peripheral Neuropathic PainTracks: Other - Other Categories: Topical Workshop Room: 718 B This workshop explores novel technologies applied to skin biopsy taken from patients with painful peripheral neuropathy as powerful tools to advance our understanding of the mechanisms by which non-neuronal cells in the skin communicate with cutaneous afferents and how this communication impacts peripheral neuropathic pain. First Dr. Lauria will provide an update on the evolution… |
| 10:45am EDT–12:15pm EDT | Translational Evidence for Pain-Cognition Interactions: Insights from Laboratory Animal, Human Experimental and Clinical StudiesTracks: Mechanisms Categories: Topical Workshop Room: 713 B Pain perception is not linearly related to nociceptive input, but is subject to many modulatory factors including cognitive processes (e.g. catastrophizing, perceived self-efficacy and distraction). Pain is not only shaped by cognitive processes, pain also interferes with cognition. Patients with chronic pain report cognitive deficits, further reducing their quality of life. Acute pain also interferes… |
| 2:00pm EDT–3:15pm EDT | Lessons for Clinicians and Researchers Across the Lifespan: What Acute Pain Research With Young Children Can Teach Us AllCategories: Plenary Lecture, Virtual Program Presented By: Prof. Rebecca Pillai Riddell Room: Plenary Room Level 800 Despite centuries of research focused on elucidating answers regarding pain, research continues to progress without a definitive essential definition. Using research from the largest longitudinal studies to date studying the development of acute pain responses over the first five years of life, the current paper reviews four key lessons about understanding pain that reverberates across… |
| 2:00pm EDT–3:15pm EDT | Neuronal Interactions With Microbes in Pain and Host DefenseCategories: Plenary Lecture, Virtual Program Presented By: Isaac Chiu Room: Plenary Room Level 800 The sensory nervous system is constantly exposed to microbes at barrier tissues such as the skin and gut. We and others have found that nociceptors can directly sense bacteria and their products to mediate pain. During gram-positive infections, nociceptors can directly detect bacterial pore-forming toxins and signal to immune cells to modulate the outcome of… |
| 4:30pm EDT–6:00pm EDT | Basic and Clinical Research Exploring Acupuncture Therapy for PainTracks: Placebo Categories: Topical Workshop Room: 717 B Acupuncture in an ancient medical technique originated in China. By inserting thin needles into body at specific anatomical locations, improvements in a range of symptoms, especially painful conditions, have been reported empirically and by many meta-analyses of clinical trials. However, the therapeutic values of acupuncture for pain management are fraught with controversy, largely due to… |
| 4:30pm EDT–6:00pm EDT | From Gut Feelings to Memories of Visceral Pain: Mechanisms and Clinical Perspectives for Disorders of Gut-Brain InteractionsTracks: Specific Pain Conditions/Pain In Specific Populations Categories: Topical Workshop Room: 713 B Visceral pain is an important yet often underestimated clinical and societal problem. From a clinical perspective, visceral pain is highly prevalent, causes enormous suffering and significant healthcare expenditures. Effective treatment is notoriously difficult, owing at least in part to its complex etiology involving the gut-brain axis. Visceral pain is highly modifiable by psychological factors, and… |
| 4:30pm EDT–6:00pm EDT | Large-Scale Studies Elucidating Pain and Sensitivity in a Life-CourseTracks: Assessment, Diagnosis & Measurement Of Pain Categories: Topical Workshop Room: 714 A The pain system undergoes structural and functional adaptation during the life course. Important stages during the life span may either prime or cause future pain conditions. Mapping pain symptoms, pain sensitivity, and pain mechanisms across life course and sex can provide important information on how the pain system is changed in pain conditions. Dr. Graven-Nielsen… |
| 4:30pm EDT–6:00pm EDT | Molecular Pathophysiology of Pain ResolutionTracks: Genetics Categories: Topical Workshop, Virtual Program Room: 718 A The molecular pathophysiology of chronic pain states is largely unknown. The genetic and molecular studies of pain in both humans and mice nevertheless can provide critical insights into pathophysiological mechanisms of pain chronification. Increasing evidence suggests that resolution of actue pain requires an active molecular process and production of specilized pro-resolving mediators (SPMs). Failure in… |
| 4:30pm EDT–6:00pm EDT | Neurobiological Mechanisms and Clinical Relevance of Stress-Pain InteractionsTracks: Mechanisms Categories: Topical Workshop Room: 715 A The relationship between stress and pain is complex and multi-layered. Stress has been known to produce hyperalgesic and hypoalgesic effects depending on various factors. Individual reactions to pain (e.g., catastrophizing) can trigger a psycho-neuro-endocrine response that negatively impacts pain. Multiple brain pathways (e.g., thalamocorticoamygdala) and systems (e.g., endogenous opioid and cannabinoid systems) are central to… |
| 4:30pm EDT–6:00pm EDT | Pain in OsteoarthritisTracks: Specific Pain Conditions/Pain In Specific Populations Categories: Topical Workshop Presented By: Dr. Robert R. Edwards, Dr. Tuhina Neogi, Kristian Kjaer Petersen, Professor Hans-Georg Schaible Room: 718 B Osteoarthritis is prevalent, and the prevalence is expected to increase in future due to increasing level of obesity and increasing age in the general population. Osteoarthritis is characterized by cartilage degeneration, joint stiffness, and pain. X-ray imaging remains the golden standard to assess cartilage generation, but no to limited association is found comparing x-ray findings… |
| 4:30pm EDT–6:00pm EDT | The Burden of Not Knowing: The Role of Uncertainty Chronic Pain DisabilityTracks: Mechanisms Categories: Topical Workshop Room: 713 A Learning to predict danger is adaptive; it assists in anticipating and avoiding harm. Given its intrinsically alarming function, pain is a potent motivator for learning –it stimulates the detection of stimuli predicting the occurrence of pain to minimize their impact. Protective responses (fear/avoidance) are adaptive and promote recovery, yet when pain no longer signals bodily… |
| 4:30pm EDT–6:00pm EDT | Utilization of Pain Biomarkers as the Basis for Decisions in the Therapeutic Development Process and in Clinical Practice: New Approaches from INTEGRATE-PainTracks: Assessment, Diagnosis & Measurement Of Pain Categories: Topical Workshop Presented By: Prof. Katy F. Vincent, Dr. Tony Blockeel, Dr. Mary Ann Pelleymounter, Dr. Laura Simons Room: 715 B The workshop will open with an introduction to the INTEGRATE-Pain consortium, which seeks to improve the understanding and treatment of pain through transatlantic R&D. It will also provide an overview of different categories of biomarkers and how each type can be integrated into the therapy development process and clinical practice. The session will then feature… |
| 4:30pm EDT–6:00pm EDT | Which Structural and Functional Changes in Skin Nociceptors Cause Chronic Pain?Tracks: Mechanisms Categories: Topical Workshop Room: 716 B The key question of this topical workshop is which neuropathic changes in epidermal nociceptors can lead to chronic pain and how can we specifically assess the underlying changes in excitability. Beyond mere nerve fiber reduction as a frequent hallmark of small fiber neuropathy (SFN), we propose to look into which cues facilitate or inhibit epidermal… |
Friday, September 23, 2022
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| 8:15am EDT–9:30am EDT | Nonopioid Analgesics Discovery and the Valley of Death – EMA401 from Concept to Clinical TrialCategories: Plenary Lecture, Virtual Program Presented By: Prof. Maree T. Smith Room: Plenary Room Level 800 Success in translating promising preclinical efficacy data for molecules from novel non-opioid analgesics discovery programs to positive clinical trial outcomes is limited, despite the large collective effort to date. Root cause analysis reveals many obstacles impeding success in preclinical to clinical research translation. One target with positive proof-of-concept clinical trial data is the angiotensin II… |
| 8:15am EDT–9:30am EDT | William D. Willis, Jr., M.D., Ph.D. Memorial Lecture Award: Using Molecular Profiling to Understand Heterogeneity of NociceptorsCategories: Plenary Lecture, Virtual Program Presented By: Prof. Patrik Ernfors Room: Plenary Room Level 800 Distinct types of sensory neurons have unique contributions to somatosensation and pain. A comprehensive classification of sensory neurons is crucial to understanding how the different types contribute to our ability to experience heat, cold, touch, and pain. Molecular and cellular insights also open for an understanding of the origins and mechanisms that cause chronic pain.… |
| 10:45am EDT–12:15pm EDT | From Cells to Humans’ Pain (and Back) – Translational Pain Research is More than Just a VisionTracks: Other - Mechanisms Categories: Topical Workshop Room: 714 B This workshop will provide a lively discussion about possible ways to approach translation pain research by three protagonists within this field. Each of the three presenters will give a brief overview about their way of performing translational pain research. Cheryl Stucky will talk about her recent translational approaches by using rodent models of chronic pain… |
| 10:45am EDT–12:15pm EDT | Non-Invasive Neuromodulation of Brain Rhythms – How Can We Translate Basic Insights into Novel Pain Treatments?Tracks: Treatment/Management Categories: Topical Workshop Room: 715 B Neuronal oscillations, or brain rhythms, are a basic feature of neuronal signaling and communication. They can be recorded at different locations and frequencies from very low frequencies below 1 Hz up to 100 Hz. Recent studies in animals and humans have provided converging evidence that brain rhythms play a crucial role in the processing of… |
| 10:45am EDT–12:15pm EDT | Novel Biomarkers in Painful Neuropathies Recent Advances in Magnetic Resonance Imaging (MRI), Microneurography, and Non-Coding RNAsTracks: Assessment, Diagnosis & Measurement Of Pain Categories: Topical Workshop Room: 701 B This workshop focuses on novel biomarkers for peripheral neuropathy and neuropathic pain. In the first session Matthew Evans will discuss the development of MR neurography, and its application to some common neuropathies such as diabetic neuropathy. He will explore the current state of the art, share experience with high field (7 Tesla) imaging of peripheral… |
| 10:45am EDT–12:15pm EDT | Pain, Substance Use Disorders and Suicide: Epidemiology, Theory, Assessment and MitigationTracks: Specific Pain Conditions/Pain In Specific Populations Categories: Topical Workshop Room: 713 A Individuals with chronic pain commonly have significant concomitant psychiatric and medical disorders placing them at higher risk for death by suicide. A seminal systematic review revealed that the risk of successful suicide was doubled in patients with chronic pain as compared to non-pain controls. Individuals with substance use disorders are also highly susceptible to suicidal… |
| 10:45am EDT–12:15pm EDT | Taking, Processing, Analyzing, Learning: Skin Punch Biopsies – More Than Just Fiber CountTracks: Novel Experimental/Analytic Approaches/Tools Categories: Topical Workshop Room: 714 A One histological hallmark of neuropathies is loss of intraepidermal nerve fibers, as shown by skin punch biopsy from the distal and proximal leg. While the procedure is fast and simple, even small but strategic inaccuracies may lead to clinically relevant misinterpretations. Following standardized guidelines for processing and analyzing skin samples is mandatory to ensure accurate… |
| 10:45am EDT–12:15pm EDT | The Intersection of Pain and the Opioid Epidemic Across the Lifespan: Scalable Behavioral SolutionsTracks: Evidence - Clinical Trials - Systematic Review - Guidelines - Implementation Science, Evidence, Clinical Trials, Systematic Review, Guidelines And Implementation Science Categories: Topical Workshop Presented By: Dr. Terri Voepel-Lewis, Dr. Marco Battaglia, Dr. Beth Darnall, Dr. Jennifer A. Rabbitts Room: 716 B Chronic pain and opioid use disorders have become significant and integrally related health concerns across the lifespan, affecting millions of individuals worldwide. Undertreated pain is a modifiable contributor to opioid misuse and use disorders. Developmental changes during adolescence make youth susceptible to chronic pain with continuation into adulthood, with pain being a primary driver of… |
| 10:45am EDT–12:15pm EDT | The Intersection of Sleep and Pain: Mechanistic Implications for Opioid, Placebo, and Positive Affective AnalgesiaTracks: Mechanisms Categories: Topical Workshop Room: 716 A Despite a clear understanding that sleep and pain consistently covary in patients with clinical pain, we have not yet translated that knowledge to produce reliable interventions that harness sleep protocols to enhance analgesia. This may be due to our limited understanding of mechanisms accounting for the association of sleep and analgesia. This workshop focuses on… |
| 10:45am EDT–12:15pm EDT | The Intersection of Trauma and Pain: Translation across Children, Adults, and AnimalsTracks: Pain In Special Populations Categories: Topical Workshop, Virtual Program Room: 718 A Painful experiences (e.g. surgeries, injuries) can be traumatic for individuals of any age, but adverse experiences and trauma in early life of humans and other mammals appear to have an important role in the development of enduring pain problems. Surprisingly little research has examined the trauma-pain relationship in early life or the underlying mechanisms that… |
| 10:45am EDT–12:15pm EDT | Understanding the Complexity of Painful Chronic Inflammatory DiseasesTracks: Specific Pain Conditions/Pain In Specific Populations Categories: Topical Workshop Presented By: Prof. Katy F. Vincent, Yvonne C. Lee, Professor Christine Norton, Dr. Nilufer Rahmioglu Room: 715 A Chronic inflammatory conditions are common. Approximately 10% women have endometriosis, ~0.5% of the adult population have a diagnosis of inflammatory bowel disease (IBD) and ~1% a confirmed diagnosis of rheumatoid arthritis. All these conditions have pain as a key symptom, yet current therapies tend to target the inflammatory pathology and the extent to which pain… |
| 1:30pm EDT–3:00pm EDT | Conditioned Pain Modulation (CPM): To Be or Not To Be?Tracks: Assessment, Diagnosis & Measurement Of Pain Categories: Topical Workshop Room: 717 A This house believes that conditioned pain modulation (CPM) is a useful tool for research and clinical work. This is based on many studies showing less efficient CPM in pain patients, especially in the nociplastic disorders, and on studies that show prediction by CPM of future pain after interventions such as surgery as well as response… |
| 1:30pm EDT–3:00pm EDT | Demystifying Mechanisms of Placebo Effects Across the LifespanTracks: Placebo Categories: Topical Workshop Room: 714 A The placebo effect is one of the most striking and well-known demonstrations of the mind’s influence on the experience of pain. While for decades clinical trials have aimed to reduce the placebo effect, there is growing interest in leveraging the placebo effect to improve pain treatments and to relieve suffering. This includes moving beyond a… |
| 1:30pm EDT–3:00pm EDT | Increasing the Capacity for Delivering Interdisciplinary Pain Management in Southeast Asia: A Model for Lower Resource RegionsTracks: Education Categories: Topical Workshop Presented By: Dr. Jimmy F. A Barus, Dr. Mary Cardosa, Professor Michael K Nicholas, Professor Zubaidah Jamil Osman Room: 718 B Despite strong evidence of the impact of pain burden globally, there is a mismatch between burden and resources for improving access to effective pain management services. This mismatch is especially evident in low resource countries. While there is often access to unimodal therapies, such as nerve blocks and drugs, they are of limited value in… |
| 1:30pm EDT–3:00pm EDT | Introducing Optical Imaging Advances to Unravel Chronic Pain MechanismsTracks: Imaging: Pain Imaging And Neuroimaging Categories: Topical Workshop, Virtual Program Room: 718 A Despite important advances in identifying molecular mechanisms in nociceptive sensitization, we are still far from treating pain disorders adequately. A major hindrance has been that the nature of neural circuits that mediate pain is not well understood and decoding how pain is generated and maintained remains a challenge. Although seminal insights have emerged from human… |
| 1:30pm EDT–3:00pm EDT | Nocebo Effects in the Covid-19 Area How Does Information About Side-Effects Influence Actual Side-Effects and How can we Mitigate These Effects? Findings Across Three ContinentsTracks: Placebo Categories: Topical Workshop Room: 715 A It is well-know that information about side-effects may lead to side-effects. Yet, less is known about the general public’s knowledge of this phenomenon and how that may decrease or increase the negative effects. The pandemic has allowed for a detailed and world-wide comparisons of how expectations of side effects influence actual side effects following COVID-19… |
| 1:30pm EDT–3:00pm EDT | Novel Peripheral Mechanisms of Neuro-Immune Crosstalk in Chronic PainTracks: Mechanisms Categories: Topical Workshop Presented By: Dr. Peter M. Grace, Dr. Andrea G Nackley, Dr. Kathleen A. Sluka, Professor Matthieu Talagas Room: 716 A This workshop will elucidate novel mechanisms whereby non-neuronal cells in peripheral tissues drive neuroinflammation and chronic pain. New data will be presented that reveal important roles for keratinocytes, adipocytes (fat cells), muscle macrophages, and B cells in the onset and maintenance of different types of chronic pain. In the first presentation, Dr. Matthieu Talagas will… |
| 1:30pm EDT–3:00pm EDT | Promoting the Engagement of Patient Partners in the Planning, Conduct and Knowledge Translation of Clinical Pain Research: Findings and Consensus Recommendations from the 2021 International Multi-Stakeholder IMMPACT MeetingTracks: Patient Engagement And Co-creation In Research And Education Categories: Topical Workshop Room: 714 B This workshop is informed by the proceedings of the October 2021 IMMPACT (Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials) Meeting: “Patient Engagement in the Planning, Conduct, and Dissemination of Clinical Pain Research.” This meeting was organized by the public-private partnership – ACTTION (Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and… |
| 1:30pm EDT–3:00pm EDT | Stress, Pain and Reward, Evolving Neuroscience with Therapeutic ImplicationsTracks: Basic Science Categories: Topical Workshop Room: 713 A The role of stress in the propensity to chronic pain is increasingly recognized. Allostasis, described as achieving stability through change, is an adaptation that accommodates potential threats through a process of learning (conditioning). A state of chronic deviation of the regulatory system from its normal (homeostatic) operating level is defined as an allostatic state. Stressors… |
| 3:15pm EDT–4:30pm EDT | Elucidating Pain Mechanism with Venom-Derived Peptides and Natural Toxins: What Doesn’t Kill You Might Treat Your PainCategories: Plenary Lecture, Virtual Program Presented By: Dr. Irina Vetter Room: Plenary Room Level 800 Pain following envenomation is a well-known phenomenon: touching a nettle, stepping on a bee or becoming wrapped in jellyfish tentacles are relatively common encounters in our lives, and all of these have in common the memorable, and at times severe, pain that results. Indeed, pain-causing venoms and toxins have evolved on numerous occasions in many… |
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Commercial exhibits are open Tuesday through Friday 09:00-18:00.
Please note: Coffee breaks overlap with Poster Discussion periods. All coffee breaks are served in the Exhibition/Poster Hall. Coffee breaks will be available on Friday afternoon from 16:00-16:15.
* Continuing education credits will not be offered by IASP for Symposia, Breakfast Symposia/Expert Sessions, Member-Supported Symposia, SIG Satellite Symposia, or Company Presentations in the Innovation Labs.