Wednesday, September 21st
Specific Pain Conditions/Pain in Specific Populations
Abnormal Reinnervation After Nerve Injury and its Effects on Pain
An injury to peripheral nerves leads to skin denervation, which often is followed by increased pain sensitivity of the denervated areas and the development of neuropathic pain. Changes in innervation patterns during the reinnervation process of the denervated skin could contribute to the development of neuropathic pain. In his talk Dr Binshtok will describe a Painbow labeling approach allowed us to determine how the innervation patterns are changing following nerve injury and the correlation of these changes with the development of neuropathic pain. Then Dr. Binshtok will introduce the realistic computational model of nociceptive primary afferent neuron which includes the terminal tree and will show how changes in the structure of the terminal tree may affect nociceptive excitability thus leading to abnormal pain.