Monday, September 19th
8:30am-12:00pm EDT


Refresher Course


Chronic pain: Other


602 B

Bench: Recent Advances and Cutting-edge Approaches in our Understanding of the CRPS Pathophysiology

In the last 2-3 years, the immune hypothesis in the development of CRPS has been strengthened. Prof. Birklein will talk about the most important work of his and other research groups on this topic. It could be shown that serum from CRPS patients is less or differently active in the degradation of inflammatory mediators and neuropeptides than serum from healthy individuals. Obviously, trauma seems to be responsible for this finding. It also fits that passive transfer of isolated IgM from patients with acute CRPS and isolated IgG from refractory patients with chronic CRPS sensitizes animals to pain when they have had prior trauma. These effects are mediated mainly by complement factors and cytokines in the spinal cord.


Professor Frank Birklein

Head, Clinical Departement of Neurology Head, Pain Research and Treatment Center
Clinical Director; Head of the Peripheral Neurology and Pain Section