Starts:

Wednesday, September 21st
8:15am-9:30am EDT

Category:

Plenary Lecture | Virtual Program

Room

Plenary Room Level 800

Cytokines and Pain

The session addresses bidirectionally crosstalk of immune cells with neurons along the pain pathway and how and these interactions are causally involved in inflammation as well as the hyperfunction of the pain pathway resulting from a disbalance of pro- and anti-inflammatory processes. In particular, the pleiotropic pro-inflammatory mediators interleukin (IL) IL-1β, IL-6, TNF-α, GM-CSF and CX3CR1 are important pro inflammatory modulators which contribute to the induction and maintenance of pathological pain. Neutralizing biologics are already in use to treat of chronic inflammatory diseases, such as rheumatoid arthritis (RA). Although not all neutralizing biologics showed effective improvement against the targeted disease, clinical trials in general documented promising safety profiles and analgesic effects. The session discusses the possibilities of repurposing currently available and approved biologics targeting pro-inflammatory cytokines as a short-cut for clinical use for patients suffering from pain disorders for which effective treatments are currently not available.

This Session is Available in Virtual Congress

Presenters

Professor Michaela Kress

Professor, Department Head
Medical University Innsbruck