Neuropathic Pain SIG Symposium

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This symposium will take place over one day consisting of interactive oral presentations from invited speakers, short oral presentations from early career researchers (awarded on a competitive basis), and ending with an interactive discussion on challenges and opportunities in the field as well as future collaboration.

Learning Objectives: 

1. At the end of this satellite participants will be able to: Utilize publicly available databases capturing human gene sequence and expression data relating to pain. 
2. Understand the functional and molecular heterogeneity of DRG neurons: how these properties may differ between rodents and humans, the effects of neural injury, and the pros and cons of native versus iPSC derived human sensory neurons. 
3. Learn how to integrate the use of human tissue into analgesic drug discovery.

 

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Schedule:

8:30 am – Early Poster Viewing, Opening Remarks, Aki Hietaharju, MD (Finland)

8:45 am -10:15 am – Recent Findings from Peripheral Tissues, Nerve Endings and Peripheral Axons with chair Simon Haroutounian, PhD (United States)

8:45 am – 9:10 am – What we can learn about neuropathic pain from Schwann cells in human skin and nerve with Claudia Sommer, MD (Germany)

9:10 am – 9:30 am – Using human bio-samples to discover mechanisms of nerve injury and pain in entrapment neuropathies with Annina Schmid, PhD (United Kingdom)

9:30 am – 9:50 am – Modulation of sensory fibers by stress exposure in patients with atopic dermatitis: Changes in itch, pain and quantitative sensory test with Macarena Tejos-Bravo (Chile)

9:30 am -9:50 am – Dissecting the relative contributions of injured and intact primary afferents to neuropathic pain with Andrew Cooper (United Kingdom)

9:50 am – 10:15 am – General Discussion, Question and Answer

10:15 am – Morning Coffee Break & Poster Viewing

10:30 am -12:00 pm – Recent Findings from Human DRG Neurons with chair Srinivasa Raja, MD (USA)

10:30 am – 10:50 am – Investigating the role of keratinocytes in painful small fiber neuropathy using human primary cultures with Margarita Calvo (Chile)

10:50 am – 11:10 am – Ectopic Discharges in Human DRG Somata and Spontaneous Pain: Data on Underlying Mechanisms with Patrick Dougherty, PhD (USA)

11:10 am – 11:30 am – Single nucleus transcriptomic findings from human DRG with Steve Davidson, PhD (USA)

11:30 am – 11:40 am –Transcriptomic and Epigenomic Atlas of the Whole Human DRG with Behrang Sharif (Canada)

11:40 am – 12:00 pm – General Discussion, Question and Answer

12:00 pm – 1:00 pm – Lunch & Poster Viewing

1:00 pm – 2:30 pm – Recent Findings from Human iPSC-derived Neurons with chair Aki Hietaharju (Finland)

1:00 pm – 1:25 pm – Translation of Preclinical Mechanisms of Neuropathic Pain in Human iPSC-derived Neurons with David Bennett, PhD (UK)

1:25 pm – 1:50 pm – Sodium Channel Mechanisms of Neuropathic Pain Modelled in Human iPSC-Derived Neurons with Angelika Lampert, MD (Germany)

1:50 pm – 2:10 pm – Forward Programmed Human Sensory Neurons for Modelling Genetic Pain Disorders with Pascal Roeder (Germany)

1:50 pm – 2:10 pm – Nav1.8 Downregulation Shifts Activity of Patient-Derived Sensory Neurons to Lower Firing with Sofie Ramisch (Germany)

2:10 pm – 2:30 pm – General Discussion, Question and Answer

2:30 pm – 3:00 pm – Afternoon Coffee Break & Poster Viewing

3:00 pm – 4:30 pm – More Findings using Human iPSC-derived neurons and Transcriptomic Findings in Human Sensory Neurons with chair Nanna Finnerup, MD (Denmark)

3:00 pm – 3:25 pm – Correlates and Differences Between Physiology Studies in Human DRG and iPSC-derived Neurons Michael Gold, Ph.D., United States

3:25 pm – 3:50 pm – Transcriptomic Findings from Human DRG: Bulk Seq and Single Cell Seq Findings with Theodore Price, PhD (USA)

3:50 pm – 4:10 pm – Deep Sequencing of Murine DRG Subpopulations After Nerve Injury with Allison Barry (United Kingdom)

3:50 pm – 4:10 pm – In Vivo Calcium Imaging Shows That Satellite Glial Cells Have Increased Activity in Painful States with Sara Jager (United Kingdom)

3:50 pm – 4:10 pm –Developing Novel Viral Vectors to Facilitate Targeted Gene Therapies for Neuropathic Pain with Paschalina Chrysostomidou (United Kingdom)

4:10 pm – 4:30 pm – General Discussion, Question and Answer

4:30 pm – Closing Remarks

 

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