About the Session
Neuropathic Pain SIG Symposium
This symposium will take place over one day consisting of interactive oral presentations from invited speakers, short oral presentations from early career researchers (awarded on a competitive basis), and ending with an interactive discussion on challenges and opportunities in the field as well as future collaboration.
Learning Objectives:
- At the end of this satellite participants will be able to: Utilize publicly available databases capturing human gene sequence and expression data relating to pain.
- Understand the functional and molecular heterogeneity of DRG neurons: how these properties may differ between rodents and humans, the effects of neural injury, and the pros and cons of native versus iPSC derived human sensory neurons.
- Learn how to integrate the use of human tissue into analgesic drug discovery.
Schedule:
8:30 – Early Poster Viewing, Opening Remarks
8:45-10:15 – Recent Findings from Peripheral Tissues, Nerve Endings and Peripheral Axons with chair Aki Hietaharju, MD, Finland
8:45-9:10 – What we can learn about neuropathic pain from Schwann cells in human skin and nerve with Claudia Sommer, MD, Germany
9:10-9:20 – Investigating the role of keratinocytes in painful small fiber neuropathy using human primary cultures with Margarita Calvo, MD, PhD, Chile
9:20-9:30 – Using human bio-samples to discover mechanisms of nerve injury and pain in entrapment neuropathies with Annina Schmid, PhD, United Kingdom
9:30-9:50 – Pain mechanisms in human distal nerve terminals
9:50-10:15 – General Discussion, Question and Answer
10:15 – Morning Coffee Break & Poster Viewing
10:30-12:00 – Recent Findings from Human DRG Neurons with chair Srinivasa Raja, MD, United States
10:30-10:55 – Pharmacological Studies of Human DRG Neurons: A Platform for Validation of New Therapeutics with Robert Gereau, III, PhD, United States
10:55-11:20 – Ectopic Discharges in Human DRG Somata and Spontaneous Pain: Data on Underlying Mechanisms with Patrick Dougherty, PhD United States
11:20-11:30 – Single nucleus transcriptomic findings from human DRG with Steve Davidson, PhD, United States
11:30-11:40 – Other Findings in Human DRG
11:40-12:00 – General Discussion, Question and Answer
12:00-13:00 – Lunch & Poster Viewing
13:00-14:30 – Recent Findings from Human iPSC-derived Neurons with chair Simon Haroutounian, MD, United States
13:00-13:25 – Translation of Preclinical Mechanisms of Neuropathic Pain in Human iPSC-derived Neurons with David Bennett, PhD United Kingdom
13:25-13:50 – Sodium Channel Mechanisms of Neuropathic Pain Modelled in Human iPSC-Derived Neurons with Angelika Lampert, Germany
13:50-14:10 – Physiology & Neurochemistry of Human iPSC-derived Neurons
14:10-14:30 – General Discussion, Question and Answer
14:30-15:00 – Afternoon Coffee Break & Poster Viewing
15:00-16:30 – More Findings using Human iPSC-derived neurons and Transcriptomic Findings in Human Sensory Neurons with chair Nanna Finnerup, MD Denmark
15:00-15:25 – Correlates and Differences Between Physiology Studies in Human DRG and iPSC-derived Neurons with Michael Gold, PhD, United States
15:25-15:50 – Transcriptomic Findings from Human DRG: Bulk Seq, Single Cell Seq and Patch Seq Findings with Theodore Price, PhD, United States
15:50-16:00 – Transcriptomic Findings in Human Spinal Neurons with Alex Chamessian, MD, United States
16:00-16:10 – Transcriptomic Findings in Human Sensory Neurons
16:10-16:30 – General Discussion, Question and Answer
16:30 – Closing Remarks
Categories Sig Symposia