Discovering New Therapeutic Targets and Molecular Pain Mechanisms Using Human Tissues: Recent Advances, Emerging Pitfalls, Continuing Gaps in Knowledge

Monday, September 19th
8:30am4:30pm EDT

About the Session

Neuropathic Pain SIG Symposium

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This symposium will take place over one day consisting of interactive oral presentations from invited speakers, short oral presentations from early career researchers (awarded on a competitive basis), and ending with an interactive discussion on challenges and opportunities in the field as well as future collaboration.

Learning Objectives: 

  1. At the end of this satellite participants will be able to: Utilize publicly available databases capturing human gene sequence and expression data relating to pain. 
  2. Understand the functional and molecular heterogeneity of DRG neurons: how these properties may differ between rodents and humans, the effects of neural injury, and the pros and cons of native versus iPSC derived human sensory neurons. 
  3. Learn how to integrate the use of human tissue into analgesic drug discovery.

 

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Schedule:

8:30 – Early Poster Viewing, Opening Remarks

8:45-10:15 – Recent Findings from Peripheral Tissues, Nerve Endings and Peripheral Axons with chair Aki Hietaharju, MD, Finland

8:45-9:10 – What we can learn about neuropathic pain from Schwann cells in human skin and nerve with Claudia Sommer, MD, Germany

9:10-9:20 – Investigating the role of keratinocytes in painful small fiber neuropathy using human primary cultures with Margarita Calvo, MD, PhD, Chile

9:20-9:30 – Using human bio-samples to discover mechanisms of nerve injury and pain in entrapment neuropathies with Annina Schmid, PhD, United Kingdom

9:30-9:50 – Pain mechanisms in human distal nerve terminals

9:50-10:15 – General Discussion, Question and Answer

10:15 – Morning Coffee Break & Poster Viewing

10:30-12:00 – Recent Findings from Human DRG Neurons with chair Srinivasa Raja, MD, United States

10:30-10:55 – Pharmacological Studies of Human DRG Neurons: A Platform for Validation of New Therapeutics with Robert Gereau, III, PhD, United States

10:55-11:20 – Ectopic Discharges in Human DRG Somata and Spontaneous Pain: Data on Underlying Mechanisms with Patrick Dougherty, PhD United States

11:20-11:30 – Single nucleus transcriptomic findings from human DRG with Steve Davidson, PhD, United States

11:30-11:40 – Other Findings in Human DRG

11:40-12:00 – General Discussion, Question and Answer

12:00-13:00 – Lunch & Poster Viewing

13:00-14:30 – Recent Findings from Human iPSC-derived Neurons with chair Simon Haroutounian, MD, United States

13:00-13:25 – Translation of Preclinical Mechanisms of Neuropathic Pain in Human iPSC-derived Neurons with David Bennett, PhD United Kingdom

13:25-13:50 – Sodium Channel Mechanisms of Neuropathic Pain Modelled in Human iPSC-Derived Neurons with Angelika Lampert, Germany

13:50-14:10 – Physiology & Neurochemistry of Human iPSC-derived Neurons

14:10-14:30 – General Discussion, Question and Answer

14:30-15:00 – Afternoon Coffee Break & Poster Viewing

15:00-16:30 – More Findings using Human iPSC-derived neurons and Transcriptomic Findings in Human Sensory Neurons with chair Nanna Finnerup, MD Denmark

15:00-15:25 – Correlates and Differences Between Physiology Studies in Human DRG and iPSC-derived Neurons with Michael Gold, PhD, United States

15:25-15:50 – Transcriptomic Findings from Human DRG: Bulk Seq, Single Cell Seq and Patch Seq Findings with Theodore Price, PhD, United States

15:50-16:00 – Transcriptomic Findings in Human Spinal Neurons with Alex Chamessian, MD, United States

16:00-16:10 – Transcriptomic Findings in Human Sensory Neurons

16:10-16:30 – General Discussion, Question and Answer

16:30 – Closing Remarks

 

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