Starts:

Friday, September 23rd
10:45am-12:15pm EDT

Category:

Topical Workshop

Tracks:

Other - Mechanisms

Room

714 B

From Cells to Humans’ Pain (and Back) – Translational Pain Research is More than Just a Vision

This workshop will provide a lively discussion about possible ways to approach translation pain research by three protagonists within this field. Each of the three presenters will give a brief overview about their way of performing translational pain research. Cheryl Stucky will talk about her recent translational approaches by using rodent models of chronic pain including inflammation, nerve injury and diseases associated with devastating pain. Her focus lies on the understanding of how ion channels on pain-sensing neurons contribute to pain, e.g. to pain of specific origin. Esther Pogatzki-Zahn will provide improvement in translational research related to acute and chronic pain after surgery, for example by improving rodent postsurgical models, using multidimensional pain behavioral approaches, unbiased proteomic studies and performing parallel studies in rodents and humans. Theodore Price will talk about his recent single-cell transcriptomics on mouse and human tissues (nociceptors and spinal cord neurons); here he comprehensively categorized similarities and differences between mouse and human cells and identified potential drug targets based on unbiased transcriptomic enrichment analysis of the human DRG and spinal cord. A discussion with the audience will focus on how the future of translational pain research will look like and research agenda should/could look like.

Presentations

Time
10:45am EDT12:15pm EDT
10:45am EDT12:15pm EDT

Innovations and Advances in Modelling and Measuring Pain in Animals and Comparisons to Human

Tracks: Other - Mechanisms
Categories: Topical Workshop
Presented By: Dr. Cheryl L Stucky

The translation of analgesic drug candidates to the clinic relies upon successful preclinical pain modelling. Dr. Stucky will discuss best practices for modeling persistent and chronic pain through choosing the most “face valid” animal models and pain behavior assays. Four fundamental decisions apply to every pain behaviour experiment: choice of subject (model organism), choice of assay (pain-inducing injury), laboratory environment and choice of outcome measures. She will discuss pros and cons of each of these four factors in making these choices. In addition, she will discuss how the use of human tissues (e.g. dorsal root ganglia, skin and plasma) which are increasingly accessible, can be used to validate the translatability of targets and mechanisms identified in animal pain models. The translation of analgesic drug candidates to the clinic relies upon successful preclinical pain modelling. Dr. Stucky will describe recent trends in the methods used to model pain in laboratory animals and provide recommendations for experimental designs that may increase translational success.

10:45am EDT12:15pm EDT

Using Human Molecular Neuroscience to Increase the Translational Potential of Preclinical Pain Research

Tracks: Other - Mechanisms
Categories: Topical Workshop
Presented By: Ted Price

Dr Price will discuss his lab’s work on profiling single cells in the human DRG and spinal dorsal horn and how this compares to mice. He will focus on how this new information can be used to focus on targets that are most translationally relevant. He will also discuss how pain assays can be developed using human DRG and spinal cord to build target validation in human tissues into therapeutic development programs.

 

Presenters

Prof. Esther Pogatzki-Zahn

Full Professor
University Hospital Muenster

Ted Price

Professor
UT Dallas

Dr. Cheryl L Stucky

Medical College of Wisconsin