Wednesday, September 21st
Assessment | Diagnosis & Measurement of Pain
How are the Comorbidities such as Fatigue, Sleep Disturbances and Cognitive Problems Related to Pain Mechanisms in Nociplastic Pain Conditions?
Prof. Clauw will dwell on the clinical relevance of co-morbidities that form part of the grading system of nociplastic pain. Both the clinical features and neurobiological underpinnings of nociplastic pain states are becoming increasingly well understood, largely because of the evolving and converging research into chronic overlapping nociplastic pain conditions such as fibromyalgia, irritable bowel syndrome, tension headache and interstitial cystitis/bladder pain syndrome. In addition to widespread/multifocal pain, other seminal clinical features include fatigue, memory and sleep issues, as well as hypersensitivity to other sensory stimuli (e.g., visual, auditory). Prof. Clauw will present data indicating that there are corresponding findings on both quantitative sensory testing (QST) and functional, chemical and structural brain neuroimaging that help explain these findings, in that the intensity of these parameters is typically closely related to report of pain and other nociplastic symptoms. Prof. Clauw will also discuss the recent evidence that the functional neuroimaging findings seen in individuals with nociplastic pain states such as insular or primary somatosensory cortex (S1) to default mode network (DMN) hyperconnectivity may actually be present in children before they develop symptoms, identifying potential vulnerability markers.