Thursday, September 22nd
Interactions Between Pain and Stress: Role of the Cannabinoid and Opioid Systems
Pain and affective state interact reciprocally, whereby the latter can both influence, and be influenced by, the pain experience. Dr. Finn will present recent research aimed at elucidating supraspinal neurochemical and receptor mechanisms involved in (1) hyperalgesia associated with negative affect (anxiety/depression), (2) fear-induced analgesia and (3) pain-induced negative affect. He will present research employing animal models including the Wistar-Kyoto rat model of hyperalgesia associated with negative affect and a rat model of fear-conditioned analgesia, coupled with behavioural pharmacology, optogenetics, and neurochemical and molecular analyses of the endogenous cannabinoid and opioid systems. He will also discuss the role of novel endocannabinoid-related targets including peroxisome proliferator-activated receptors, and consider clinical relevance and implications.