Wednesday, September 21st
4:30pm-6:00pm EDT


Topical Workshop | Virtual Program




718 A

Mechanisms of Susceptibility/Resistance to Chronic Pain Development

Basic and clinical chronic pain research has been focused on the individuals that manifest pain and on the mechanisms sustaining pain and related comorbidities. However, a relevant number of clinically characterized subjects, on similar conditions, do not manifest pain. Factors underlying such susceptibility/resistance to chronic pain development remain largely unknown though a relevant number of studies mainly on postsurgical pain reveal that unfavorable pain trajectories are associated with anxiety, depression and pain catastrophizing. In this workshop we will present and discuss novel studies that have been revealing neurophysiological states, psychobiological mechanisms and molecular environments that prior or circa pain onset explain the behavioral differences between susceptible and resistant individual as well as offering relevant cues on the mechanisms conferring pain protection. Professor Fiona Blyth will present on the risk factors underlying common pain trajectories. Professor Herta Flor will present new psychobiological data on learning-related brain mechanisms pertaining to common and distinctive profiles of pain susceptibility across different clinical pain conditions. Prof. Hugo Leite-Almeida, will present (endo)phenotypical manifestations of pain susceptibility/resistance present prior to pain onset in rodent models of chronic pain as well as potential targets to manipulate such susceptibility/resistance.

This Session is Available in Virtual Congress


4:30pm EDT6:00pm EDT

Factors of Susceptibility/Resistance to Chronic Pain in a Peripheral Neuropathy Model

Tracks: Mechanisms
Categories: Topical Workshop, Virtual Program

Experimental chronic neuropathic pain models have been selected on the basis of their ability to mimic relevant aspects of the human pathology and it is a relatively rare event to find neuropathic animals with no pain-related manifestations.
In this talk, I will present recent findings on such small population of pain resistant rats, on their phenotypical manifestations not only after, but more importantly, prior to the installation of a peripheral neuropathy. Our data show that in such scenario, animals are more pro-social and present better performance in cognitive flexibility tasks. Also, pain resistant animals present higher levels of anti-inflammatory cytokines and distinct lymphocytes levels when compared to pain susceptible rats. Finally, we demonstrate that the manipulating of the inflammatory environment at the time of the neuropathic injury can confer a long lasting protection.

4:30pm EDT6:00pm EDT

Lifecourse Approaches and Risk of Developing Chronic Pain Trajectories

Tracks: Mechanisms
Categories: Topical Workshop, Virtual Program

In this talk I will present a lifecourse framework to contextualise how studies of risk factors for pain can be thought about in terms of risk accumulation over time, and also of critical periods during which specific risk exposures may influence the onset and subsequent trajectories of chronic pain in population subgroups. This will provide the basis for an overview of what is currently understood about common pain trajectories that have been identified in epidemiological studies, and the risk exposures that may underpin them.

4:30pm EDT6:00pm EDT


Professor Fiona M. Blyth

Director Clinical Epidemiology Program
University of Sydney

Professor Herta Flor

Scentific Director
CIMH/Heidelberg University

Prof. Hugo Leite-Almeida

Universidade do Minho