Monday, September 19th
8:30am-12:00pm EDT


Refresher Course


601 B

Neuro-Immune Interactions in Autonomic Nervous System (Dys)Function

Nerve injuries often lead to chronic neuropathic pain associated with peripheral and central neuro-immunological activation and inflammatory responses of injured tissue. Within these, a wide range of soluble factors including neuropeptides, classical neurotransmitters, cytokines, and other molecules mediate complex cross-talk among nerves and immune cells. These neuroimmune interactions are bidirectional and occur at multiple levels, including peripheral barriers such as the skin and mucosal surfaces, lymphoid organs as well as the central (CNS) and peripheral nervous system (PNS). Within the PNS, sensory afferents and autonomic efferents not only coordinate responses suited to preserve tissue integrity but also may initiate or maintain abnormal function. Evidence from experimental models indicate that neuroimmune interactions contribute to the pathophysiology of several disorders, beyond others complex regional pain syndrome. Different disorders with autonomic dysfunction and their associated neuro-immune interactions will be presented and discussed within this talk.


Professor Janne Gierthmühlen

Senior physician and researcher
Universitätsklinikum Schleswig-Holstein, Campus Kiel; Sektion neurologische Schmerzforschung und -therapie