Starts:

Monday, September 19th
1:00pm-4:30pm EDT

Category:

Refresher Course

Room

601 B

Nociception and Neuroplasticity: Peripheral and Central Mechanisms

The peripheral and central nervous systems work in concert to alert us to touch and/or painful stimulation. Peripheral inflammatory mediators alter the threshold of primary sensory neurons and anatomically may restrict pain to the site of injury. However, in chronicity, the responsiveness of sensory nerve endings increases in magnitude and this impacts central processing. The physiology and anatomy of the pain system is altered and spinal events, controlling final pain perception, are maladaptive. In this refresher course we will discuss the intricate mechanisms that underlie afferent nerve stimulation, peripheral and central sensitisation and spinal cord/brain encoding of pain. Further we will discuss ''what does all this mean to the clinic?'' Peripheral and central mechanisms of plasticity contribute to the establishment and/or maintenance of chronic pain states, which manifest clinically in patients as hyperalgesia and allodynia. The clinical relevance of the pathways discussed will be explained in terms of their translational relevance and thus their potential to reveal novel therapeutic targets.

Presentations

Time
1:00pm EDT4:30pm EDT

Central Modulation of Pain

Categories: Refresher Course

This presentation will review current knowledge about descending modulation of pain from preclinical and clinical investigations.

1:00pm EDT4:30pm EDT

Nociceptors, Key Peripheral Generators of Signals Causing Acute and Chronic Pain

Categories: Refresher Course
Presented By: Ted Price

My lecture will focus on recent advances in molecular identification of nociceptor subtypes in animals and humans, with a focus on what we currently know about how human nociceptors are sensitized and how these nociceptors contribute to chronic pain states. The lecture will cover findings from animal studies, but will focus on state-of-the-art findings on human nociceptors.

1:00pm EDT4:30pm EDT

The Anatomy and Physiology of the Pain System

Categories: Refresher Course
Presented By: Dr. Kirsty Bannister

The peripheral and central nervous systems work in concert to alert us to touch and/or painful stimulation. Peripheral inflammatory mediators alter the threshold of primary sensory neurons and anatomically may restrict pain to the site of injury. However, in chronicity, the responsiveness of sensory nerve endings increases in magnitude and this impacts central processing. The physiology and anatomy of the pain system is altered and spinal events, controlling final pain perception, are maladaptive. In this refresher course we will discuss the intricate mechanisms that underlie afferent nerve stimulation, peripheral and central sensitisation and spinal cord/brain encoding of pain.
Further we will discuss ''what does all this mean to the clinic?'' Peripheral and central mechanisms of plasticity contribute to the establishment and/or maintenance of chronic pain states, which manifest clinically in patients as hyperalgesia and allodynia. The clinical relevance of the pathways discussed will be explained in terms of their translational relevance and thus their potential to reveal novel therapeutic targets.

Presenters

Dr. Kirsty Bannister

Associate Professor
King's College London

Professor Frank Porreca

Professor
University of Arizona

Ted Price

Professor
UT Dallas