Tuesday, September 20th
Nociceptor Sensitization – News From Patients and Patient-Derived In Vitro Systems at the Neuro-Cutaneous Unit
Neuropathic pain may be caused by diverse etiologies and it is intriguing that the same etiology may lead to a painful condition or remain painless. While until recently, pain generation and perception were exclusively associated with neuronal tissue, scientists have increasingly turned research focus to non-neuronal cells and their potential influence on the development of neuropathic pain. Skin cells are of particular interest since they tightly surround nociceptors and may influence nerve fiber growth and sensitivity. In this presentation, data on the potential influence of the neuro-cutaneous unit on neuropathic pain development will be summarized giving clinical examples and patient-derived in vitro systems. The audience will experience a lively and exciting journey spanning a bow from clinical research based on thorough pain phenotyping and biomaterial analysis to cutting-edge in vitro models that may guide the way to efficient systemic and local analgesic treatment.