Peripheral Neuroimmune Interactions Drive Itch and Inflammation

Atopic dermatitis (AD) is the most common chronic itch disorder and affects ~10% of people worldwide. AD is an inflammatory disease associated with skin barrier disruption, inflammation, spontaneous activity of C-fibers, persistent itch, and, in a subset of patients, persistent pain. This talk will highlight the peripheral neuroimmune interactions that drive the development of itch in AD and the transition from an acute to chronic inflammatory disease state.