Starts:

Monday, September 19th
1:00pm-4:30pm EDT

Category:

Refresher Course

Tracks:

Placebo

Room

701 B

Placebo and Nocebo Effects: Basic Science and Implications for Clinical Trials and Clinical Practice

During the last decade, psychological and neurobiological mechanisms underlying placebo and nocebo effects have been identified and by now it is possible to outline how this knowledge may influence the design and outcome of clinical trials as well as to which extent these effects can be optimized in clinical practice in ethically appropriate ways. In this refresher course, Wager will outline the state-of-the-art of psychological and neurobiological underpinnings of placebo effects including racial and ethnic disparities and illustrate how to predict individual difference in placebo responses in trials as well as discuss the relationship between placebo and other psychological interventions in clinical practice. Colloca will give an overview of how nocebo effects are conceptualized across American and European populations, and outline the latest knowledge of nocebo mechanisms including racial differences in addition to discussing the ethical dilemmas of applying knowledge of placebo and nocebo effects to clinical practice. Finally, Vase will illustrate how placebo and nocebo mechanisms may influence the outcome of clinical tests across pharmacological and non-pharmacological interventions and suggest how this knowledge can be taken into consideration in the design and the interpretation of experimental studies and clinical trials as well as in the findings from clinical practice.

Presentations

Time
1:00pm EDT4:30pm EDT

Can Knowledge of Placebo Mechanisms Help Optimize Clinical Trials?

Tracks: Placebo
Categories: Refresher Course
Presented By: Lene Vase

The magnitude of placebo and nocebo responses have been shown to influence assay sensitivity (i.e. the ability of a trial to distinguish an effective treatment from a less effective or ineffective intervention). Dr. Vase will illustrate how recent knowledge of placebo and nocebo mechanisms may improve design and interpretations of pharmacological and non-pharmacological trials with the overall aim of clarifying the effects of treatments.

1:00pm EDT4:30pm EDT

Mechanisms and Mitigation of Nocebo Hyperalgesia

Tracks: Placebo
Categories: Refresher Course
Presented By: Prof. Luana Colloca

Traditionally nocebo effects have been investigated to a lesser extent than placebo effects partly due to ethical restrictions concerning the investigation of potentially pain increasing procedures. Recently, however, marked progress in the understanding of nocebo mechanisms have been made and Colloca will give an overview of the latest knowledge of nocebo mechanisms including definition, conceptualizations across countries and ethnic disparities. In addition, Colloca will illustrate novel approaches to mitigate nocebo effects effect in clinical practice and discuss ethical dilemmas related to this practice.

1:00pm EDT4:30pm EDT

Mechanisms and Prediction of Placebo Analgesia

Tracks: Placebo
Categories: Refresher Course
Presented By: Prof. Tor D. Wager

During the last decade profound progress has been made in the understanding of the mechanisms underlying placebo analgesia effects. Wager will outline the state-of-the-art of psychological and neurobiological underpinnings of placebo effects including racial and ethnic disparities. Recently, there has been an increased interest in understanding placebo responses in clinical trials with the aim to improve the detection of the true drug-placebo ratio. Wager will illustrate how to predict individual difference in placebo responses in clinical trials and discuss the implications for the test of drug efficacy. In addition, he will discuss the relationship between placebo and other psychological interventions in clinical practice with the aim to understand how treatment effects can be optimized in clinical practice.

Presenters

Lene Vase

Professor
Aarhus University

Prof. Tor D. Wager

Diana L. Taylor Distinguished Professor
Dartmouth College

Prof. Luana Colloca

MPower Distinguished Professor
University of Maryland, School of Nursing