Pro-Nociceptive and Anti-Nociceptive Mechanisms in Spinal Pain

This presentation will focus on factors that may influence pain modulatory mechanisms. Here, the focus will be on how pain modulatory mechanisms present in people with spinal pain, how they may change over time in relation to the experience of experimental and clinical back pain episodes, and how they may be modified by attentional manipulation, affective manipulation, lifestyle factors and clinical features. The presentation will include an overview of the state of the literature on pain modulation in people with spinal pain, as well as data from a series of experimental and clinical studies in people across a spectrum of low back pain presentations, to illustrate how pain modulatory mechanisms are impacted by clinical spinal pain presence and manipulation of attentional and affective demands.