Tuesday, September 20th
Schwann Cell Extracellular Vesicles Are Innovative Regulators Of Neuroinflammation And Pain
Several studies have revealed that Schwann cells (SCs) release small extracellular vesicles (EVs).
EVs are small nanovesicles and include exosomes.
Initially, exosomes were thought to be a cellular mechanism of waste disposal but are now also considered to be highly specific enablers of cellular communication. Importantly, exosomes reflect the status of their originating cells.
This talk will introduce novel SC EV mechanisms that regulate PNS physiology, during injury and
associated with the development of neuropathic pain. Focus will be on 1) proteins specifically sequestered in the plasma membranes of SC EVs that are bioactive, 2) SC EV tumor necrosis factor-receptor 1 (TNFR1) and how they serve as a TNF a
“decoy” and modify TNFα activities (including inhibiting stress activated cell signaling (p38 MAPK), regulate expression of other cytokines and influence SC morphology and viability), and 3) on novel ways that SC EVs modulate neuroinflammation and pain. The presentation will highlight the innovative aspects of SC EV biology, as it relates to neuropathic pain.