Schwann Cell Renaissance In Pain: Critical Appraisal Of New Knowledge On Old Cells

The primary reason for inadequate analgesic effects of current pharmaceuticals for neuropathic pain is that we do not fully understand the pathophysiological mechanisms that underlie its development. We will discuss ground-breaking novel findings on potential peripheral mechanisms of neuropathic pain concentrating on the skin-nerve interface and presenting potential implications on clinical practice. Data from clinical and preclinical studies will be discussed critically focusing on Schwann cells that are experiencing a renaissance, now in neuropathic pain pathophysiology. We will present new data that address whether or not skin Schwann cells are likely to be important in the generation or maintenance of neuropathic pain. The workshop will start with a presentation by Professor Campana, who will present new data on how extracellular vesicles from Schwann cells serve as multi-functional regulators of physiology and pathological changes, possibly controlling neuropathic pain. Associate Professor Karlsson will review the many challenges for quantifying Schwann cells, and he will compare Schwann cell densities between patients with and without diabetic neuropathy. Professor Üçeyler will present data from clinical studies with regard to cutaneous Schwann cells and patient-derived in vitro systems focusing on the skin-nerve interface and potential mechanisms that may contribute to the pathophysiology of neuropathic pain.