Starts:

Tuesday, September 20th
10:45am-12:15pm EDT

Category:

Topical Workshop

Tracks:

Mechanisms

Room

713 A/B

Schwann Cells In Patients With Painless and Painful Diabetic Peripheral Neuoropathy

The pathological hallmark in patients with painful neuropathies is a significant loss of intraepidermal nerve fibers. However, the simple count of intraepidermal nerve fibers does not explain why some, but not all, neuropathic patients develop neuropathic pain. It is, however, possible to perform much more detailed analysis of the skin biopsies. This talk will introduce new findings on detailed skin biopsy analysis related to neuropathic pain, with a special focus on the nociceptive Schwann cells. This specialized cutaneous glial cell type was recently introduced. However, the nociceptive Schwann cells have never been quantified before. Additionally, it remains unclear, whether or not there are morphological or functional differences of the Schwann cells between patients with and without neuropathic pain. Here, I will present novel ways to quantify the Schwann cells in both animal and human skin, address the many challenges and pitfalls when doing so, and present the nociceptive Schwann cell density in both animal models of type 1 diabetic DPN as well as in humans with type 1 diabetes, DPN without neuropathic pain and in patients with painful DPN, and correlate the findings with signs and symptoms of DPN.

Presenters

Dr. Pall R. Karlsson

Associate professor
Aarhus University