Tuesday, September 20th
4:30pm-6:00pm EDT


Topical Workshop


Assessment, Diagnosis & Measurement of Pain


718 B

Sensory Testing is Useful for Stratifying Patients with Chronic Pain in Treatment and Clinical Trials

Quantitative Sensory Testing can assess multiple aspects of the sensory nervous system, including peripheral and central aspects, sensation and pain thresholds, and integrity of various pathways. Using comprehensive protocols in a standardized way, QST can thus paint a picture of the individual sensory alterations of each patient. Some of the emerging patterns have been linked to well-characterized surrogate models, indicating a link between patterns seen in patients and mechanistic studies. Although only few studies have been prospectively designed to test differential treatment response, the existing evidence points towards that specific treatments will be more efficient for patient groups with certain sensory patterns. It has also been shown that QST profiles change in response to worsening of the condition or improvement due to disease-modifying treatment. Thus, QST has demonstrated all elements of a biomarker: differentially responsive to treatment, linked to plausible mechanisms of disease, and responsive to changes in disease.


Jan Vollert

Research Fellow
Imperial College London