Friday, September 23rd
10:45am-12:15pm EDT


Topical Workshop


Specific Pain Conditions/Pain in Specific Populations


715 A

Understanding the Complexity of Painful Chronic Inflammatory Diseases

Chronic inflammatory conditions are common. Approximately 10% women have endometriosis, ~0.5% of the adult population have a diagnosis of inflammatory bowel disease (IBD) and ~1% a confirmed diagnosis of rheumatoid arthritis. All these conditions have pain as a key symptom, yet current therapies tend to target the inflammatory pathology and the extent to which pain is experienced varies widely between individuals, with little (if any) relationship between severity of pain and measures of disease severity. Interestingly these conditions are frequently comorbid, suggesting that they may share common underlying mechanisms, however, because they affect specific organ systems and are cared for by distinct specialties (gynaecologists, gastroenterologists and rheumatologists respectively) there is little overlap in research and clinical practice. This session will consider three areas of importance to our understanding of pain in chronic inflammatory conditions: genetics, pain mechanisms and the lived experience. The presentations will each focus on one of the conditions but explore the overlap with the other diseases, areas for translation between the conditions and for further collaborative research will be highlighted and further developed in the discussion time.


10:45am EDT12:15pm EDT

Chronic Inflammatory Diseases and Pain

Tracks: Specific Pain Conditions/Pain In Specific Populations
Categories: Topical Workshop
Presented By: Prof. Katy F. Vincent

This brief introductory presentation will describe the three conditions to be covered in the workshop and review the extent to which they are associated with chronic pain. Key areas to be covered in the workshop will then be highlighted as an introduction to the main presentations.

10:45am EDT12:15pm EDT

Pain Mechanisms in Rheumatoid Arthritis: Overlap and Distinguishing Characteristics Compared to other Chronic Pain Conditions

Tracks: Specific Pain Conditions/Pain In Specific Populations
Categories: Topical Workshop
Presented By: Yvonne C. Lee

Musculoskeletal pain is the leading cause of disability in the world, and the number one reason patients with arthritis visit healthcare providers. Safe and effective, non-opioid analgesics are lacking, and over half of patients with inflammatory arthritis report pain, despite treatment with strong immunomodulatory drugs. Our research team was one of the first to show that patients with rheumatoid arthritis (RA) have impairments in pain processing, consistent with CNS pain sensitization, otherwise termed nociplastic pain. Once established, nociplastic pain often occurs in the absence of detectable peripheral inflammation. Inflammation may, however, serve as a trigger for developing nociplastic pain and/or be a factor in maintaining nociplastic pain. In animal models, an acute episode of inflammation can prime the hyperalgesic response to a second stimulus, resulting in long-lasting hyperalgesia. In humans, there is an increased prevalence of fibromyalgia (FM), the prototypical nociplastic pain condition, among patients with chronic inflammatory diseases, including RA, endometriosis, and inflammatory bowel disease. Little is known, however, about the cellular, physiologic, and biopsychosocial pathways that drive the transition from acute peripheral/visceral pain to chronic nociplastic pain in these diseases. In this presentation, we will review existing literature and discuss challenges and opportunities for future interdisciplinary research.

10:45am EDT12:15pm EDT

Tailoring Treatment Strategies to the Patient Experience of Pain in Inflammatory Bowel Disease

Tracks: Specific Pain Conditions/Pain In Specific Populations
Categories: Topical Workshop

This presentation will draw on qualitative and quantitative research exploring the patient experience of pain and treatment options in Inflammatory Bowel Disease. The implications for treatment strategies that include both biomedical and cognitive behavioural aspects will be presented, emphasising a partnership between the patient and the multidisciplinary team when managing pain. Similarities and differences with patient experience of pain in endometriosis and RA will also be explored, including whether similar pain management strategies might be indicated.  

10:45am EDT12:15pm EDT

The Genetic Basis of Endometriosis and Comorbid Pain Conditions

Tracks: Specific Pain Conditions/Pain In Specific Populations
Categories: Topical Workshop
Presented By: Dr. Nilufer Rahmioglu

This presentation will give an overview of the latest findings in understanding the genetic basis of endometriosis, from the largest collaborative studies to date. Specifically, as yet unpublished results from the International Endometriosis Genome Consortium (24 datasets; >60,000 cases and >700,000 controls) will be presented that have uncovered 42 genome-wide significant loci (31 novel), and that show significant genetic correlation with other pain and inflammatory conditions. We will also present additional work using the UK Biobank and other data resources, in which we uncover, and dive deeper, into a shared genetic basis for endometriosis, rheumatoid arthritis and osteoarthritis. We are about to submit the study results for publication in two high impact journals, and therefore presentation in this IASP workshop will be timely.


Prof. Katy F. Vincent

Associate Professor, Senior Fellow in Pain in Women
University of Oxford

Yvonne C. Lee

Associate Professor
Northwestern University Feinberg School of Medicine

Professor Christine Norton

Professor of Clinical Nursing Research
King's College London

Dr. Nilufer Rahmioglu

Senior Research Fellow
University of Oxford