Starts:

Wednesday, September 21st
10:45am-12:15pm EDT

Category:

Topical Workshop | Virtual Program

Tracks:

Treatment/Management

Room

718 A

What’s New in Combination Pharmacotherapy for Neuropathic Pain? From Bench to Bedside

Laura Stone will illustrate the therapeutic potential of combination pharmacotherapy by highlighting – with recent examples – additive and synergistic analgesic interactions using preclinical investigative techniques. The rationale for picking certain targets for combinations will be presented as will issues of adverse drug interactions. Ian Gilron will provide a recently updated evidence-based review of combination pharmacotherapy for neuropathic pain in order to highlight critical issues surrounding optimal combinations and necessary improvements for future combination trials. Key issues relating to combination therapy will be discussed including: 1) safety 2) simultaneous versus sequential “add-on” therapy; and 3) optimal use of fixed dose combinations. Flemming Bach will discuss combination pharmacotherapy in the context of real-world neuropathic pain. This will include a review of safe and effective evidence-based pain management practices by discussing known adverse drug interactions. The challenges and limitations of combination therapy with currently available drugs will also be presented. In particular consideration of the narrow therapeutic window due to cognitive side effects represent an obstacle and calls for consideration of alternative combination approaches.

This Session is Available in Virtual Congress

Presentations

Time
10:45am EDT12:15pm EDT

Clinical Research and Evidence Surrounding Combination Pharmacotherapy for Neuropathic Pain

Tracks: Treatment/Management
Categories: Topical Workshop, Virtual Program
Presented By: Ian Gilron

Ian Gilron will provide a recently updated evidence-based review of combination pharmacotherapy for neuropathic pain in order to highlight critical issues surrounding optimal combinations and necessary improvements for future combination trials. Key issues relating to combination therapy will be discussed including: 1) safety 2) simultaneous versus sequential “add-on” therapy; and 3) optimal use of fixed dose combinations.

10:45am EDT12:15pm EDT

Combination Pharmacotherapy in Real-World Management of Neuropathic Pain

Tracks: Treatment/Management
Categories: Topical Workshop, Virtual Program

Flemming Bach will discuss combination pharmacotherapy in the context of real-world neuropathic pain. This will include a review of safe and effective evidence-based pain management practices by discussing known adverse drug interactions. The challenges and limitations of combination therapy with currently available drugs will also be presented. In particular consideration of the narrow therapeutic window due to cognitive side effects represent an obstacle and calls for consideration of alternative combination approaches.

 

10:45am EDT12:15pm EDT

Preclinical Approaches to the Understanding and Development of Analgesic Combination Therapy

Tracks: Treatment/Management
Categories: Topical Workshop, Virtual Program
Presented By: Dr. Laura S. Stone

Dr. Stone will illustrate the therapeutic potential of combination pharmacotherapy by highlighting additive and synergistic analgesic interactions using pre-clinical investigative techniques. The rationale for picking certain targets for combinations will be presented as will issues of adverse drug interactions.

Presenters

Prof. Flemming W. Bach

Professor, Consultant
Aarhus University Hospital

Ian Gilron

Professor
Queen's University

Dr. Laura S. Stone

Professor
University of Minnesota