College of Medicine and Public Health


Flinders University and South Australian Health and Medical Research Institute



Prof. Stuart Brierley

BSc, PhD

Stuart Brierley is an international leader on the ‘Gut-Brain’ axis, in particular the different afferent classes innervating the gut, the channels and receptors underlying their function and how these mechanisms are changed in acute and chronic visceral pain. This has been possible by developing novel techniques (including mouse colonic afferent recordings) and combining them with molecular biology, genetically modified mice, optogenetics, and clinically relevant models of acute and chronic visceral pain, human biospecimens and translational science. This includes using human DRG neurons for functional and RNA analysis to determine coupling of ion channels and GPCRs in health and disease to determine how the first in class guanylate cyclase-C (GC-C) agonist linaclotide (Linzess) inhibits colonic nociception, the role of NaV1.1 in mechanical pain and the role of enterochromaffin cells in visceral hypersensitivity.


Monday, September 19, 2022

1:00pm EDT4:30pm EDT

An Evidence-Based Approach to Chronic Abdominopelvic Pain

Tracks: Visceral, Abdominal And Pelvic Pain
Categories: Refresher Course
Room: 602 B

Chronic abdominopelvic pain is a major public health problem worldwide, yet it is poorly understood and treated, with both pelvic…

Wednesday, September 21, 2022

4:30pm EDT6:00pm EDT

Contribution of Itch, Inflammation, and the Microbiota to Colorectal Nociception: Opportunities for Therapeutic Intervention?

Tracks: Mechanisms
Categories: Topical Workshop
Room: 713 A

Visceral pain is a leading cause of morbidity for individuals suffering from gastrointestinal (GI) diseases. For many people the principal…